1985-88-2

Basic information

• Product Name: 4-Chloro-2-methyl-2-butanol
• Synonyms: 4-Chloro-2-methyl-2-butanol;2-Butanol, 4-chloro-2-Methyl-;4-Chloro-2-methylbutan-2-ol
• CAS NO: 1985-88-2
• Molecular Formula: C₅H₁₁ClO
• Molecular Weight: 122.6
• Product Categories: All Aliphatics;Aliphatics
• Mol File: 1985-88-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 178.6 °C at 760 mmHg
• Flash Point: 81.4 °C
• Appearance: /
• Density: 1.021 g/cm³
• Vapor Pressure: 0.295mmHg at 25°C
• Refractive Index: 1.438
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Ethyl Acetate
• PKA: 14.87±0.29(Predicted)
• CAS DataBase Reference: 4-Chloro-2-methyl-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-methyl-2-butanol(1985-88-2)
• EPA Substance Registry System: 4-Chloro-2-methyl-2-butanol(1985-88-2)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 1985-88-2(Hazardous Substances Data)

Usage

Description

4-Chloro-2-methyl-2-butanol, with the CAS number 1985-88-2, is an organic compound characterized by its clear, colorless to pale orange oily appearance. It is primarily utilized in the field of organic synthesis, where it serves as a valuable intermediate for the creation of various chemical products.

Uses

Used in Organic Synthesis:
4-Chloro-2-methyl-2-butanol is used as a synthetic intermediate for the production of a wide range of chemical compounds. Its unique structure, which includes a chlorine atom and a methyl group, allows it to participate in various chemical reactions, making it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Chloro-2-methyl-2-butanol is used as a key component in the development of new drugs. Its chemical properties enable it to be transformed into various drug candidates, potentially leading to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Agrochemical Industry:
4-Chloro-2-methyl-2-butanol also finds application in the agrochemical industry, where it is employed in the synthesis of new pesticides and other crop protection agents. Its incorporation into these products can enhance their performance, leading to more effective solutions for managing pests and diseases in agriculture.
Used in Specialty Chemicals:
In the specialty chemicals sector, 4-Chloro-2-methyl-2-butanol is utilized for the production of various high-value chemicals with specific applications. These may include additives for the plastics and polymer industry, fragrances and flavorings, or other advanced materials with unique properties.

InChI:InChI=1/C5H11ClO/c1-5(2,7)3-4-6/h7H,3-4H2,1-2H3

Upstream product

• 2568-33-4 3-methyl-butane-1,3-diol 
• 623-71-2 ethyl 3-chloropropanoate 
• 6322-49-2 4-chloro-2-butanone 
• 917-64-6 methyl magnesium iodide 
• 676-58-4 methylmagnesium chloride 
• 78-94-4 methyl vinyl ketone 
• 75-16-1 methylmagnesium bromide 
• 103603-61-8 2,5-dihypochloro-2,5-dimethylhexane 
• 107-84-6 1-chloro-3-methylbutane 
• 624-96-4 1,3-dichloro-3-methylbutane 
• 6001-87-2 methyl 3-chloropropionate 
• 78-79-5 isoprene 

Downstream Products

• 83945-76-0 25-fluoro-22(S)-hydroxycholesterol 
• 15936-45-5 N-prenylphthalimide 
• 1294453-62-5 4-(4-bromo-3,5-dimethyl-phenoxy)-2-methyl-butan-2-ol 
• 1458656-71-7 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-3-methylbutoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid 
• 1459-04-7 3-chloro-1,1-dimethyl-1-phenylpropane 
• 2049-95-8 tery-amylbenzene 
• 113058-90-5 3,4,5-trimethoxy-benzoic acid-(1,1-dimethyl-3-morpholino-propyl ester) 
• 624-96-4 1,3-dichloro-3-methylbutane 
• 6245-99-4 2,2-dimethyl-oxetane 

Relevant articles and documents

PROCESS AND INTERMEDIATES FOR PREPARING GPR40 AGONISTS

The present invention relates to compounds of formula I wherein RS denotes F or CF3, Ra denotes H or C1-4-alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as

Use of xanthine derivatives for reducing the pathological hyperreactivity of eosinophilic granulocytes, novel xanthine compounds and process for their preparation

Use of xanthine derivatives for reducing the pathological hyperreactivity of eosinophilic granulocytes, novel xanthine compounds and process for their preparation. Tertiary 1-(hydroxyalkyl)-4-alkylxanthines are suitable for the production of pharmaceuticals for the treatment of disorders which is associated with a pathologically increased reactivity of eosinophilic granulocytes. Novel xanthine derivatives and process for their preparation are described.

22-Hydroxycholesterol Derivatives as HMG CoA Reductase Suppressors and Serum Cholesterol Lowering Agents

A series of 22-hydroxycholesterol derivatives with a modified side chain terminus was prepared.These agents were evaluated in vitro and in vivo for their ability to suppress HMG CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis.In tissue culture assays, 22-hydroxycholesterol as well as the side chain modified analogues were potent inhibitors of HMG CoA reductase.However, only those sterols with a modified side chain terminus were effective suppressors of liver reductase whene administered ig to rats. 22-Hydroxy-25-methylcholesterol (4a) and 25-fluoro-22-hydroxycholesterol (15a) significantly lowered serum cholesterol levels when administered ig to primates; 25-chloro-22-hydroxycholesterol (15b) and the analogue with a cyclopropyl terminus, 20b, were ineffective.The cholesterol-lowering sterols did not significantly alter lipoprotein levels; however, the two compounds have been shown to inhibit acyl-coenzyme A:cholesterol-transferase (ACAT) in tissue culture studies