20173-49-3

Basic information

• Product Name: PYRIDINE, 2-CHLORO-5-METHYL-, 1-OXIDE
• Synonyms: PYRIDINE, 2-CHLORO-5-METHYL-, 1-OXIDE;2-Chloro-5-methylpyridine 1-oxide;2-chloro-5-Methylpyridine-1-o×ide;2-chloro-5-methyl-1-oxidopyridin-1-ium
• CAS NO: 20173-49-3
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.572
• Mol File: 20173-49-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 320.166 °C at 760 mmHg
• Flash Point: 147.431 °C
• Appearance: /
• Density: 1.229 g/cm³
• PKA: -0.52±0.10(Predicted)
• CAS DataBase Reference: PYRIDINE, 2-CHLORO-5-METHYL-, 1-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE, 2-CHLORO-5-METHYL-, 1-OXIDE(20173-49-3)
• EPA Substance Registry System: PYRIDINE, 2-CHLORO-5-METHYL-, 1-OXIDE(20173-49-3)

Safety Data

• Hazardous Substances Data: 20173-49-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-methylpyridine N-oxide is a chemical compound with the formula C6H6ClNO. It is a colorless to pale yellow liquid that is used as a reactant in organic synthesis. It is also used in the production of pharmaceuticals and agrochemicals, as well as in the synthesis of other chemical compounds. 2-Chloro-5-methylpyridine N-oxide is a stable compound that is mildly reactive and has low acute toxicity, making it suitable for use in various industrial processes. It is important to handle this chemical with care and follow proper safety protocols when working with it.

Upstream product

• 18368-64-4 2-chloro-5-methylpyridine 
• 100047-39-0 2-nitro-5-methylpyridine-N-oxide 
• 75-36-5 acetyl chloride 
• 4931-47-9 N-(5-methylpyridin-2-yl)acetamide 
• 66362-95-6 2-amino-5-methylpyridine-N-oxide 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 

Downstream Products

• 58596-88-6 2,6-dichloro-3-methyl-5-nitropyridine 
• 53179-13-8 Pirfenidone 
• 202217-19-4 6-chloro-5-methyl-3-nitropyridin-2-amine 
• 869886-95-3 4-[2-(S)-(1-acetoxymethylpropylamino)-5-methylpyridin-4-yl]-1-(2,4,6-trimethylbenzensulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 79055-62-2 2-chloro-5-methyl-pyridin-4-ylamine 
• 1610362-87-2 2-(benzylamino)-5-methylpyridine 1-oxide 
• 58584-94-4 2,6-dichloro-3-methylpyridine 
• 56961-78-5 2,4-dichloro-5-methylpyridine 
• 60323-96-8 2-chloro-5-methyl-4-nitropyridine 1-oxide 

Relevant articles and documents

IMPROVED METHODS, KITS, COMPOSITIONS AND DOSING REGIMENS FOR THE USE OF HETEROCYCLIC INHIBITORS OF ERK1 AND ERK2

The present application provides improved compositions, methods, kits and dosing regimens for the use of heterocyclic compounds and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, or stereoisomers thereof. These compositions, methods, kit

2-hydroxy-4-amino-5-picoline heterocyclic compounds

The invention discloses a 2-hydroxy-4-amino-5-methylpyridine heterocyclic compound which can be used as an intermediate for synthesizing an omeprazole compound. The invention further discloses a synthesis method of a 2-hydroxy-4-amino-5-methylpyridine heterocyclic compound. The synthesis method comprises four steps of synthesis of 2-chloro-5-methylpyridine nitrogen oxide, synthesis of 2-chloro-4-nitro-5-methylpyridine nitrogen oxide, synthesis of 2-chloro-4-amino-5-methylpyridine and synthesis of 2-hydroxy-4-amino-5-methylpyridine. The synthesis method of the 2-hydroxy-4-amino-5-methylpyridine heterocyclic compound disclosed by the invention is simple, reaction raw materials are low in price, and a synthesis route is environment-friendly.

Fluorescence polarization for the evaluation of small-molecule inhibitors of PCAF BRD/Tat-AcK50 association

A fluorescence polarization competitive assay was developed to efficiently screen and evaluate inhibitors of PCAF bromodomain/Tat-AcK50 protein-peptide interaction. A series of pyridine 1-oxide derivatives were synthesized and evaluated. Some of the novel