210644-62-5 Usage
Description
SU 6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against various receptor tyrosine kinases (RTKs), including Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), and FGFR1. It is also known to target ser/thr kinases such as Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK, as well as non-receptor TKs Lyn and Yes. SU 6668 has been shown to inhibit PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo.
Uses
Used in Pharmaceutical Industry:
SU 6668 is used as a PDGFR Tyrosine Kinase Inhibitor VI for its potent ATP-competitive inhibition against tyrosine kinases, which plays a crucial role in the development and progression of various cancers.
Used in Cancer Research:
SU 6668 is used as a research tool for studying the role of receptor tyrosine kinases in cancer cell growth, angiogenesis, and tumor development. Its ability to inhibit multiple kinases makes it a valuable compound in understanding the complex signaling pathways involved in cancer progression.
Used in Drug Development:
SU 6668 is used as a lead compound in the development of novel therapeutic agents targeting receptor tyrosine kinases and other ser/thr kinases, with potential applications in the treatment of various types of cancer.
Used in Angiogenesis Inhibition:
SU 6668 is used as an inhibitor of angiogenesis, the process through which new blood vessels form from pre-existing ones. This property makes it a potential therapeutic agent for conditions where inhibition of blood vessel growth is desired, such as in cancer treatment.
Used in Tumor Development Studies:
SU 6668 is used to study the role of PDGF/VEGF/bFGF-mediated signaling in tumor development, providing insights into the molecular mechanisms underlying cancer progression and the potential for targeted therapeutic intervention.
Check Digit Verification of cas no
The CAS Registry Mumber 210644-62-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,0,6,4 and 4 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 210644-62:
(8*2)+(7*1)+(6*0)+(5*6)+(4*4)+(3*4)+(2*6)+(1*2)=95
95 % 10 = 5
So 210644-62-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9-
210644-62-5Relevant articles and documents
DIHYDROINDOLE DERIVATIVES USEFUL IN PARKINSON'S DISEASE
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Page/Page column 15, (2009/04/25)
The invention relates to novel heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis
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, (2008/06/13)
The present invention relates to methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis. More specifically, this invention relates to methods for treating diseases and disorders, such as rheumatoid arthritis,
Pyrrole substituted 2-indolinone protein kinase inhibitors
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, (2008/06/13)
The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
