217-90-3Relevant articles and documents
DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands
Zeng, Pengfei,He, Limin,Ye, Zhenfeng,Yang, Ning,Song, Yulan,Lu, Jiazheng
, p. 779 - 787 (2015)
Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated.
Synthesis and characterization of ruthenium complexes with substituted pyrazino[2,3-f][1,10]-phenanthroline (= RPPL; R = ME, COOH, COOME)
Delgadillo, Alvaro,Romo, Paola,Leiva, Ana Maria,Loeb, Barbara
, p. 2110 - 2120 (2003)
A series of substituted pyrazino[2,3-f][1,10]-phenanthroline (Rppl) ligands (with R = Me, COOH, COOMe) were synthetized (see 1-4 in Scheme 1). The ligands can be visualized as formed by a bipyridine and a quinoxaline fragment (see A and B). Homoleptic [Ru(R1ppl)3](PF6)2 and heteropleptic [Ru(R1ppl){(R2)2bpy}2] (PF6)2 (R1 = H, Me, COOMe and R2 = H, Me) metal complexes 5-7 and 8-13, respectively, based on these ligands were also synthesized and characterized by conventional techniques (Schemes 2 and 3, resp.). In the heteroleptic complexes, the R1-ppl ligand reduces at a less-negative potential than the bpy ligand, reflecting the acceptor property conferred by the quinoxaline moiety. The potentiality of some of these complexes as solar-cell dyes is discussed.
Ru(ii) photosensitizers competent for hypoxic cancersviagreen light activation
Ballester, Francisco J.,Bautista, Delia,Ortega, Enrique,Ruiz, José,Santana, M. Dolores
supporting information, p. 10301 - 10304 (2020/09/16)
A family of five heteroleptic complexes [Ru(C^N)(N^N)2][PF6] (HC^N = methyl 1-butyl-2-arylbenzimidazolecarboxylate; N^N = polypyridine) has been synthesized to act as biologically-compatible green light photosensitizers (PSs) with phototherapeutic indexes (PIs) up to higher than 700 under hypoxia (2% O2) in HeLa cancer cells under short time of irradiation.
A series of blue-green-yellow-red emitting Cu(I) complexes: Molecular structure and photophysical performance
Zhang, Liming,Zuo, Qinghui
, (2019/06/25)
In this work, we designed a series of [Cu(N–N)(PPh3)2]BF4 complexes with different optical edge values and emission colors from blue to red, where N–N and PPh3 denoted a diamine ligand and triphenylphosphine, respectively. Six N–N ligands with various conjugation chains (short π chain, modest π chain and long π chain) were selected. A systematical comparison between these Cu(I) complexes was performed, so that the correlation between N–N structure and [Cu(N–N)(PPh3)2] photophysical performance was tentatively discussed. Their single crystal structure was found consistent with literature ones, forming a typical tetrahedral coordination geometry. Density functional theory calculation indicated that their onset electronic transition showed a mixed character of metal-to-ligand-charge-transfer and ligand-to-ligand-charge-transfer. Detailed analysis on photophysical parameters suggested that the absorption edge of [Cu(N–N)(PPh3)2]BF4 complex was controlled by conjugation length in diamine ligand. A wide absorption edge needed a short conjugation chain in diamine ligand. Similar tendency was found for their emission spectra. In addition, a long conjugation chain in diamine ligand widened emission spectra obviously. Emission dynamics showed slim correlation with diamine ligand conjugation length since the excited state was controlled mainly by dynamic procedure and steric factor of diamine ligands.
