22009-37-6

Basic information

• Product Name: 7-Methyl-1-tetralone
• Synonyms: 7-METHYL-1-TETRALONE;3,4-dihydro-7-methyl-1(2h)-naphthalenon;3,4-dihydro-7-methyl-1(2H)-Naphthalenone;3,4-dihydro-7-methylnaphthalen-1(2H)-one;7-Methyl-3,4-dihydro-2H-naphthalen-1-one;4-dihydro-7-Methyl-;7-Methyl-3,4-dihydronaphthalen-1(2H)-one;1(2H)-Naphthalenone,3,4-dihydro-7-methyl-
• CAS NO: 22009-37-6
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.21
• EINECS: 244-717-9
• Mol File: 22009-37-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 35-36 °C
• Boiling Point: 287.1°C at 760 mmHg
• Flash Point: 121.1°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 0.00253mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dichloromethane; Ethyl Acetate
• CAS DataBase Reference: 7-Methyl-1-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methyl-1-tetralone(22009-37-6)
• EPA Substance Registry System: 7-Methyl-1-tetralone(22009-37-6)

Safety Data

• Hazardous Substances Data: 22009-37-6(Hazardous Substances Data)

Usage

Description

7-Methyl-1-tetralone is a ketone derivative that serves as an intermediate in organic synthesis, particularly in the production of various compounds with potential antimicrobial, antifungal, and anti-inflammatory properties.

Uses

Used in Pharmaceutical Industry:
7-Methyl-1-tetralone is used as an intermediate in the synthesis of (±)-cis-Calamenene, a sesquiterpene and volatile metabolite derived from Salvia fruticosa plants. 7-Methyl-1-tetralone has potential applications as an antimicrobial, antifungal, and anti-inflammatory agent, making it valuable in the development of new pharmaceuticals for treating various infections and inflammations.
Used in Organic Synthesis:
7-Methyl-1-tetralone is also used as an intermediate in the synthesis of 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile, which is an intermediate for creating phthalazinone scaffolds. These scaffolds are potent inhibitors of poly(ADP-ribose) polymerase, an enzyme involved in various cellular processes, including DNA repair and genomic stability. The development of inhibitors targeting this enzyme can have significant implications in the treatment of certain diseases and conditions.

InChI:InChI=1/C11H12O/c1-8-5-6-9-3-2-4-11(12)10(9)7-8/h5-7H,2-4H2,1H3

Upstream product

• 104115-64-2 2-bromo-7-methyl-1,2,3,4-tetrahydronapthalin-1-one 
• 121-69-7 N,N-dimethyl-aniline 
• 160699-02-5 4-(4-methylphenyl)butanoyl chloride 
• 71-43-2 benzene 
• 1680-51-9 6-methyl-1,2,3,4-tetrahydronaphthalene 
• 59618-44-9 4-(3-methylphenyl)-4-oxobutanoic acid 
• 62164-86-7 4-(m-tolyl)but-3-enoic acid 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 22156-45-2 4-(m-tolyl)butanoic acid 
• 36978-51-5 5-oxo-5-(m-tolyl)pentanoic acid 
• 108-88-3 toluene 
• 96-48-0 4-butanolide 
• 7719-09-7 thionyl chloride 
• 4521-22-6 4-(4-methylphenyl)butyric acid 

Downstream Products

• 102080-30-8 6-methyl-4-phenethyl-1,2-dihydro-naphthalene 
• 6938-37-0 (+/-)-1-Hydroxy-1.7-dimethyl-1.2.3.4-tetrahydro-naphthalin 
• 56137-91-8 7-methyl-naphthyl-1-acetic acid 
• 19723-03-6 7-methyl-1-phenylnaphthalene 
• 58472-26-7 2-hydroxy-7-methylnaphthalene-1,4-dione 
• 25095-39-0 (7-Methyl-naphthalen-1-yl)-acetic acid hydrazide 
• 63039-88-3 9-methyl-12,13-dihydro-7H-dibenzo[a,g]carbazole 
• 2606-85-1 2-methylbenzo[c]phenanthrene 
• 110050-91-4 7-methyl-2-phenethyl-1,2,3,4-tetrahydro-[1]naphthol 
• 102662-82-8 7-methyl-1-oxo-2-phenethyl-1,2,3,4-tetrahydro-[2]naphthoic acid ethyl ester 
• 51015-29-3 6-methyl-3,4-dihydronaphthalen-1(2H)-one 
• 101735-31-3 2-Methyl-8-benzyl-naphthalin 
• 100266-83-9 6,11-Dimethyl-benzofluoranthen 
• 5462-81-7 7-methyl-3,4-dihydronaphthalen-1(2H)-one oxime 

Relevant articles and documents

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Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) that causes severe motor, sensory, and cognitive impairments. Kallikrein-related peptidase (KLK)6 is the most abundant serine protease secreted in the CNS, mainly by oligodendrocytes, the myelin-producing cells of the CNS, and KLK6 is assumed to be a robust biomarker of MS, since it is highly increased in the cerebrospinal fluid (CSF) of MS patients. Here, we report the design and biological evaluation of KLK6's low-molecular-weight inhibitors, para-aminobenzyl derivatives. Interestingly, selected hit compounds were selective of the KLK6 proteolytic network encompassing KLK1 and plasmin that also participate in the development of MS physiopathology. Moreover, hits were found noncytotoxic on primary cultures of murine neurons and oligodendrocyte precursor cells (OPCs). Among them, two compounds (32 and 42) were shown to promote the differentiation of OPCs into mature oligodendrocytes in vitro constituting thus emerging leads for the development of regenerative therapies.

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.

An Electrophilic Trifluoromethylthiolation of Silylenol Ethers and β-Naphthols with Diethylaminosulfur Trifluoride and (Trifluoromethyl)trimethylsilane

An efficient and general trifluoromethylthiolation of silylenol ethers and β-naphthols have been accomplished employing the combination of diethylaminosulfur trifluoride (DAST) and (trifluoromethyl)trimethylsilane (CF3TMS) as source of electrophilic trifluoromethylthio moiety for the synthesis of α-trifluoromethylthiolated carbonyl compounds and β-naphthols in good yields. Important features of this method include wide functional group tolerance and use of readily available DAST/CF3TMS. Potential of the methodology was demonstrated via the synthesis of α-trifluoromethylthiolated (+)-4-cholesten-3-one and naphthoquinone. (Figure presented.).