22156-45-2

Basic information

• Product Name: 4-(M-tolyl)butanoic acid
• Synonyms: 4-(M-tolyl)butanoic acid;Benzenebutanoic acid, 3-Methyl-
• CAS NO: 22156-45-2
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• EINECS: -0
• Mol File: 22156-45-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(M-tolyl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(M-tolyl)butanoic acid(22156-45-2)
• EPA Substance Registry System: 4-(M-tolyl)butanoic acid(22156-45-2)

Safety Data

• Hazardous Substances Data: 22156-45-2(Hazardous Substances Data)

Upstream product

• 59618-44-9 4-(3-methylphenyl)-4-oxobutanoic acid 
• 103324-39-6 1-(3-bromopropyl)-3- methylbenzene 
• 92848-10-7 (3-Methyl-phenaethyl)-malonsaeure 
• 91552-42-0 4-(4-chloro-3-methyl-phenyl)-butyric acid 
• 591-17-3 meta-bromotoluene 
• 1490-25-1 succinic acid monomethylester chloride 
• 855658-72-9 (3-methyl-phenethyl)-malonic acid diethyl ester 
• 585-74-0 3-Methylacetophenone 
• 625-38-7 but-3-enoic acid 
• 17933-03-8 m-tolylboronic acid 
• 3333-20-8 1-allyl-3-methylbenzene 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 62164-86-7 4-(m-tolyl)but-3-enoic acid 
• 108-88-3 toluene 

Downstream Products

• 51015-29-3 6-methyl-3,4-dihydronaphthalen-1(2H)-one 
• 22009-37-6 7-methyl-3,4-dihydro-2H-naphthalen-1-one 
• 5462-81-7 7-methyl-3,4-dihydronaphthalen-1(2H)-one oxime 
• 6939-35-1 5-methyl-1-tetralone 
• 29304-60-7 7-methyl-4-phenyl-1,2-dihydronaphthalene 

Relevant articles and documents

Ligand-Controlled Regiodivergence in Nickel-Catalyzed Hydroarylation and Hydroalkenylation of Alkenyl Carboxylic Acids**

A nickel-catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochemical outcome. Markovnikov hydrofunctionalization products are obtained under mild ligand-free conditions, with up to 99 % yield and >20:1 selectivity. Alternatively, anti-Markovnikov products can be accessed with a novel 4,4-disubstituted Pyrox ligand in excellent yield and >20:1 selectivity. Both electronic and steric effects on the ligand contribute to the high yield and selectivity. Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the optimal ligand. DFT calculations reveal that in the anti-Markovnikov pathway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1° versus 2°) in the rate- and regioselectivity-determining transmetalation transition state.

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE

A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof. This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.