6939-35-1

Basic information

• Product Name: 5-METHOXY-1-TETRALONE
• Synonyms: 5-METHYL-1-TETRALONE;3,4-dihydro-5-methylnaphthalen-1(2H)-one;1(2H)-Naphthaleone,3,4-dihydro-5-methyl;5-Methyltetralin-1-one;1(2H)-Naphthalenone, 3,4-dihydro-5-methyl-;Einecs 230-073-6;Nsc 57011;5-Methyl-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 6939-35-1
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 176.21
• EINECS: 251-723-5
• Mol File: 6939-35-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 87-91 °C(lit.)
• Boiling Point: 160-162 °C7 mm Hg(lit.)
• Flash Point: 122.7 °C
• Appearance: /
• Density: 1.074 g/cm³
• Vapor Pressure: 0.00214mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-METHOXY-1-TETRALONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-1-TETRALONE(6939-35-1)
• EPA Substance Registry System: 5-METHOXY-1-TETRALONE(6939-35-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: QK4800000
• Hazardous Substances Data: 6939-35-1(Hazardous Substances Data)

Usage

General Description

5-Methoxy-1-Tetralone, also scientifically known as 3,4-Dihydro-5-methoxy-1(2H)-naphthalenone, is a chemical compound related to the class of organic compounds known as naphthalenes. These compounds contain a naphthalene moiety, which consists of two fused benzene rings. This specific compound, 5-Methoxy-1-Tetralone, has two primary functionalities: the ketone at the 1-position and the methoxy group at the 5-position. Known for its high reactivity, this compound typically exists as a light yellow liquid and is often used as an intermediate in the synthesis of other chemical substances, especially in pharmaceutical and medicinal chemistry. It is seldom found in its natural state, but more commonly produced in a laboratory setting.

InChI:InChI=1/C11H12O/c1-8-4-2-6-10-9(8)5-3-7-11(10)12/h2,4,6H,3,5,7H2,1H3

Upstream product

• 23203-29-4 4-(4-tert-butyl-2-methyl-phenyl)-butyric acid 
• 2809-64-5 5-methyltetralin 
• 77970-22-0 5-Methyl-3,4,5,8-tetrahydro-2H-naphthalen-1-one 
• 7446-70-0 aluminium trichloride 
• 859809-70-4 4-o-tolyl-butyryl chloride 
• 36978-51-5 5-oxo-5-(m-tolyl)pentanoic acid 
• 2373-76-4 2-methylcinnamic acid 
• 41010-06-4 4-(o-tolyl)butanenitrile 
• 22084-89-5 3-(2-methylphenyl)propanoic acid 
• 951247-74-8 C₁₁H₁₆O₃S 
• 22156-45-2 4-(m-tolyl)butanoic acid 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 62164-86-7 4-(m-tolyl)but-3-enoic acid 
• 59618-44-9 4-(3-methylphenyl)-4-oxobutanoic acid 

Downstream Products

• 858439-60-8 8-methyl-4-phenethyl-1,2-dihydro-naphthalene 
• 571-61-9 1,5-dimethylnaphthalene 
• 858199-17-4 8-methyl-4-phenyl-1,2-dihydro-naphthalene 
• 23203-37-4 5-methyl-3,4-dihydro-2H-naphthalen-1-one semicarbazone 
• 192987-41-0 4-[1-(1-hydroxy-5-methyl-1,2,3,4-tetrahydronaphthyl)]-N-(triphenylmethyl)imidazole 
• 1612867-50-1 (2Z,4E)-4-[5'-methyl-3′,4′-dihydro-1′(2′H)-naphthalen-1′-ylidene]-3-methyl-2-butenoic acid 
• 6337-29-7 3-(4-hydroxy-5,6-dihydro-4H-phenalen-1-yl)-propionic acid 
• 861093-83-6 1-methyl-5-phenethyl-naphthalene 
• 23702-40-1 1-Oxo-5-methyl-2-(2-isobutyryl-cyclohexyl)-tetralin 
• 23203-36-3 5-methyl-3,4-dihydro-2H-naphthalen-1-one-(2,4-dinitro-phenylhydrazone) 

Relevant articles and documents

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.

Enantioselective halogenative semi-pinacol rearrangement: Extension of substrate scope and mechanistic investigations

The present Full Paper article discloses a survey of our recent results obtained in the context of the enantioselective halogenation-initiated semi-pinacol rearrangement. Commencing with the fluorination/semi-pinacol reaction first and moving to the heavier halogens (bromine and iodine) second, the scope and limitations of the halogenative phase-transfer methodology will be discussed and compared. An extension of the fluorination/semi-pinacol reaction to the ring-expansion of five-membered allylic cyclopentanols will be also described, as well as some preliminary results on substrates prone to desymmetrization will be given. Finally, the present manuscript will culminate with a detailed mechanistic investigation of the canonical fluorination/semi-pinacol reaction. Our mechanistic discussion will be based on in situ reaction progress monitoring, complemented with substituent effect, kinetic isotopic effect and non-linear behaviour studies.

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.