221354-43-4

Basic information

• Product Name: 2-<4-methyl-2-(methoxy)phenyl>-1-tetrahydro-2H-1,4-oxazin-4-yl-1-ethanthione
• Synonyms: 2-<4-methyl-2-(methoxy)phenyl>-1-tetrahydro-2H-1,4-oxazin-4-yl-1-ethanthione
• CAS NO: 221354-43-4
• Molecular Weight: 265.376
• Mol File: 221354-43-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-<4-methyl-2-(methoxy)phenyl>-1-tetrahydro-2H-1,4-oxazin-4-yl-1-ethanthione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<4-methyl-2-(methoxy)phenyl>-1-tetrahydro-2H-1,4-oxazin-4-yl-1-ethanthione(221354-43-4)
• EPA Substance Registry System: 2-<4-methyl-2-(methoxy)phenyl>-1-tetrahydro-2H-1,4-oxazin-4-yl-1-ethanthione(221354-43-4)

Safety Data

• Hazardous Substances Data: 221354-43-4(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 35633-35-3 2-methoxy-4-methylacetophenone 
• 122-46-3 3-acetoxytoluene 
• 6921-64-8 4'-hydroxy-2'-methylacetophenone 

Downstream Products

• 64052-99-9 rel-(3S,3aS,8bS)-7-bromo-3,6,8b-trimethyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-3a-carbaldehyde 
• 331626-90-5 methyl 2-(2-methoxy-4-methylphenyl)propanethiolate 
• 65817-24-5 3,6-dimethyl-3H-benzo[b]furan-2-one 
• 238752-82-4 methyl 2-[4-methyl-2-(methyloxy)phenyl]-5-hexenethioate 
• 221354-52-5 methyl 2-<4-methyl-2-methoxyphenyl>ethanethioate 

Relevant articles and documents

Total syntheses of aplysin and debromoaplysin using a diastereoselective, sulfur mediated radical cyclisation strategy

Total syntheses of two marine sesquiterpenes, aplysin 1 and debromoaplysin 2, are described. The key step involves a diastereoselective, sulfur mediated radical cyclisation of diene 5 to 7 which simultaneously creates the sterically demanding aplysin skeleton and establishes the relative configuration of the three contiguous stereogenic centres.

A simple and direct method for converting thioamides into thioesters

Thioamides may be transformed into thioesters through the simple expedient of warming them in an aqueous THF solution containing an alkylating agent. Reactions proceed in high yield and are amenable to multi-gram scale.