227963-15-7

Basic information

• Product Name: (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid
• CAS NO: 227963-15-7
• Molecular Weight: 439.514
• Mol File: 227963-15-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 122 °C
• Boiling Point: 735.5±60.0 °C(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid(227963-15-7)
• EPA Substance Registry System: (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid(227963-15-7)

Safety Data

• Hazardous Substances Data: 227963-15-7(Hazardous Substances Data)

Usage

Description

(S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid is a complex chemical compound with a unique molecular structure. It features a pyridine ring with a methoxy substitution, an imidazolidin-1-yl group, and a tetrahydro-1,8-naphthyridin-2-yl group. Additionally, it contains a propanoic acid moiety with a ketone functional group. (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid may exhibit various biological activities or pharmaceutical applications, but further research is necessary to establish its specific properties and potential uses.

Uses

Used in Pharmaceutical Industry:
(S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid is used as a potential pharmaceutical candidate for [application reason] due to its complex molecular structure and the presence of various functional groups that may interact with biological targets.
Used in Chemical Research:
In the field of chemical research, (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid serves as a subject for studying [application reason], such as its reactivity, stability, or potential to form new compounds with desired properties.

Upstream product

• 24108-29-0 3-(2-methyl-[1,3]dioxolan-2-yl)-propionaldehyde 
• 1628-89-3 2-methoxypyridine 
• 339555-43-0 tert-butyl (3S)-3-amino-3-(6-methoxypyridin-3-yl)propanoate 4-methylbenzenesulfonate 
• 339555-47-4 tert-butyl (3S)-3-(6-methoxypyridin-3-yl)-3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-2,3-dihydro-1H-imidazol-1-yl}propanoate 
• 227751-86-2 tert-butyl (3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)carbamate 
• 339555-45-2 tert-butyl (3S)-3-[(2,2-dimethoxyethyl)amino]-3-(6-methoxypyridin-3-yl)propanoate 
• 227751-85-1 tert-butyl (3-(1,8-naphthyridin-2-yl)propyl)carbamate 
• 342648-58-2 dimethyl 5-[(tert-butoxycarbonyl)amino]-2-oxopentylphosphonate 
• 339555-31-6 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)prop-2-enenitrile 
• 339555-33-8 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)prop-2-enenitrile 
• 204452-91-5 3(S)-(6-methoxypyridin-3-yl)-3-alanine tert-butyl ester p-toluenesulfonic acid 
• 204452-90-4 2-(dimethoxymethyl)-1,8-naphthyridine 
• 204452-93-7 5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carboxaldehyde 
• 206989-41-5 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propane-1-amine 

Relevant articles and documents

Thermodynamic Understanding of an Aza-Michael Reaction Enables Five-Step Synthesis of the Potent Integrin Inhibitor MK-0429

We describe a general strategy for the aza-Michael addition of nucleophilic heterocycles into β-substituted acrylates using potassium tert-butoxide as catalyst. Demonstrating that the reaction is under thermodynamic control underpins optimization efforts and enables rapid exploration of the substrate scope, with yields ranging from 55% to 94%. We further leverage these lessons in a significantly shortened synthesis of MK-0429, a potent pan-integrin inhibitor previously taken into human clinical trials for the treatment of prostate cancer and osteoporosis.

An efficient synthesis of an alphavbeta3 antagonist.

A practical preparation of an alpha(v)beta(3) antagonist is reported. The antagonist consists of three key components, a tetrahydronaphthyridine moiety, a beta-alanine moiety, and a central imidazolidone moiety. The tetrahydronaphthyridine component was p

Process and intermediates for the preparation of imidazolidinone αv integrin antagonists

A novel process is provided for the preparation of imidazolidinone αvβ3/αvβ5 integrin antagonists, and the useful intermediates obtained therein. These compounds are antagonists of αvβ3/αvβ5 integrin receptors and thus useful for inhibiting bone resorption and treating and preventing osteoporosis. Also disclosed is 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]imidazolidin-1-yl}-3(S)-(6-methoxy-pyridin-3-yl)-propionic acid in the form of a hemihydrate.