23877-12-5Relevant articles and documents
Catalytic synthesis method of tert-butyl alpha-bromoisobutyrate by using cation exchange resin
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Paragraph 0032; 0033; 0034, (2016/12/01)
The invention relates to a catalytic synthesis method of tert-butyl alpha-bromoisobutyrate by using cation exchange resin, and belongs to the technical field of synthetic organic chemistry synthesis. The method use alpha-bromoisobutyrate and isobutylene as raw materials; the raw materials are supplemented with a solvent and a polymerization inhibitor and subjected to an esterification reaction by using a cation exchange resin as a catalyst, so as to obtain the tert-butyl alpha-bromoisobutyrate. The cation exchange resin is one or more selected from D001, D003, CH-A, CH-B, 732, and CHR-06. The invention solves the problems of large amount of wastewater, serious equipment corrosion and high content of polymer in the prior art; the prepared product has yield of 80-90% and purity higher than 98%; and the selected cation exchange resin has the characteristics of high catalytic activity, good selectivity, small equipment corrosion, long service life, easiness to recycle and reuse, low energy consumption and less wastewater generation, and has high economic values for reducing production costs, safety and environmental protection.
Prodrugs activated by targeted catalytic proteins
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, (2008/06/13)
Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.