254-04-6 Usage
Description
2H-chromene, also known as chroman or chromane, is the simplest member of the class of chromene compounds. It features a heterocyclic pyran ring with a double bond between positions 3 and 4, which contributes to its unique chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
2H-chromene is used as a key structural component in the development of various pharmaceutical compounds. Its presence in the molecular structure can influence the biological activity and pharmacological properties of the resulting drug candidates. The heterocyclic ring system of 2H-chromene allows for easy modification and functionalization, making it a versatile building block for designing new drugs with specific therapeutic targets.
Used in Chemical Synthesis:
2H-chromene serves as an important intermediate in the synthesis of more complex organic molecules. Its unique chemical structure allows for various synthetic transformations, such as oxidation, reduction, and substitution reactions. These reactions can lead to the formation of a wide range of chemical products, including natural products, agrochemicals, and other specialty chemicals.
Used in Material Science:
The unique properties of 2H-chromene make it a potential candidate for the development of new materials with specific applications in material science. For example, its ability to form stable complexes with other molecules can be exploited to create novel materials with enhanced properties, such as improved stability, selectivity, or reactivity.
Used in Research and Development:
2H-chromene is also used as a research tool in various scientific fields, including organic chemistry, medicinal chemistry, and biochemistry. Its unique chemical properties and reactivity make it an interesting subject for studying fundamental chemical reactions and exploring new synthetic pathways. Additionally, its potential applications in drug discovery and material science make it a valuable compound for researchers working on the development of new technologies and products.
Check Digit Verification of cas no
The CAS Registry Mumber 254-04-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,5 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 254-04:
(5*2)+(4*5)+(3*4)+(2*0)+(1*4)=46
46 % 10 = 6
So 254-04-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H8O/c1-2-6-9-8(4-1)5-3-7-10-9/h1-6H,7H2
254-04-6Relevant articles and documents
Synthesis of 2 h-chromenes via hydrazine-catalyzed ring-closing carbonyl-olefin metathesis
Jermaks, Janis,Lambert, Tristan H.,Macmillan, Samantha N.,Zhang, Yunfei
, p. 9259 - 9264 (2019/10/08)
The catalytic ring-closing carbonyl-olefin metathesis (RCCOM) of O-Allyl salicylaldehydes to form 2H-chromenes is described. The method utilizes a [2.2.1]-bicyclic hydrazine catalyst and operates via a [3 + 2]/retro-[3 + 2] metathesis manifold. The nature of the allyl substitution pattern was found to be crucial, with sterically demanding groups such as adamantylidene or diethylidene offering optimal outcomes. A survey of substrate scope is shown along with a discussion of mechanism supported by DFT calculations. Steric pressure arising from syn-pentane minimization of the diethylidene moiety is proposed to facilitate cycloreversion.
Iron-catalysed borylation of arenediazonium salts to give access to arylboron derivatives via aryl(amino)boranes at room temperature
Marciasini, Ludovic D.,Richy, Nicolas,Vaultier, Michel,Pucheault, Mathieu
, p. 1083 - 1088 (2013/05/21)
Complementary to previously described Miyaura borylation methods, a new access to boron derivatives via aryl(amino)boranes is described. Direct coupling between aryldiazonium salts and diisopropylaminoborane is catalysed by 0.1% ferrocene leading to the formation of a carbon-boron bond. The obtained aryl(amino)boranes could eventually then be transformed into boronic acids, boronates or borates. Copyright
Novel electrochemical route to 2-(α-alkoxyallyl)phenols - Cathodic eliminative ring opening reaction
Bhuvaneswari,Venkatachalam,Balasubramanian
, p. 1409 - 1412 (2007/10/02)
Electrochemical reduction of 4-alkoxy-3-bromochromans in acetonitrile led to a facile ring cleavage reaction yielding (2(α-alkoxy- allyl)phenols which are not easily accessible.
