254762-83-9

Basic information

• Product Name: N-benzyl-N-(4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-but-2-ynyl)-hydroxylamine
• Synonyms: N-benzyl-N-(4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-but-2-ynyl)-hydroxylamine
• CAS NO: 254762-83-9
• Molecular Weight: 347.573
• Mol File: 254762-83-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-(4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-but-2-ynyl)-hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-(4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-but-2-ynyl)-hydroxylamine(254762-83-9)
• EPA Substance Registry System: N-benzyl-N-(4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-but-2-ynyl)-hydroxylamine(254762-83-9)

Safety Data

• Hazardous Substances Data: 254762-83-9(Hazardous Substances Data)

Upstream product

• 622-30-0 N-benzyl hydroxylalmine 
• 100-52-7 benzaldehyde 
• 622-32-2 (Z)-benzaldehyde oxime 
• 76782-82-6 tert-Butyldimethyl(prop-2-ynyloxy)silane 
• 105623-17-4 (Z)-N-(2-methylpropylidene)benzylamine N-oxide 

Relevant articles and documents

Synthesis of 2,3-dihydroisoxazoles from propargylic N-hydroxylamines via Zn(II)-catalyzed ring-closure reaction

(equation presented) A novel cyclization reaction of propargylic N-hydroxylamines to 2,3,5-trisubstituted 2,3-dihydroisoxazoles in the presence of catalytic amounts (10 mol %) of ZnI2 and DMAP is reported. The methodology provides a mild new approach to this useful class of substituted heterocycles that complements extant methods. The unique reactivity of the propargylic N-hydroxylamine substrates in the presence of Zn(II) and DMAP may have additional applications in other, related alkyne cyclization reactions.