2585-23-1

Basic information

• Product Name: N-Methyl-4-Nitro-Benzamide
• Synonyms: N-Methyl-4-Nitro-Benzamide;Benzamide, N-methyl-p-nitro-;MFCD01211871
• CAS NO: 2585-23-1
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16072
• Mol File: 2585-23-1.mol
• Article Data: 42

Chemical Properties

• Melting Point: 219 °C
• Boiling Point: 382.6 °C at 760 mmHg
• Flash Point: 185.2 °C
• Appearance: /
• Density: 1.272 g/cm³
• Vapor Pressure: 4.65E-06mmHg at 25°C
• Refractive Index: 1.569
• PKA: 13?+-.0.46(Predicted)
• CAS DataBase Reference: N-Methyl-4-Nitro-Benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-4-Nitro-Benzamide(2585-23-1)
• EPA Substance Registry System: N-Methyl-4-Nitro-Benzamide(2585-23-1)

Safety Data

• Hazardous Substances Data: 2585-23-1(Hazardous Substances Data)

Usage

General Description

N-Methyl-4-Nitro-Benzamide is a chemical compound with the molecular formula C8H8N2O3. It is a yellow crystalline solid that is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. N-Methyl-4-Nitro-Benzamide is known for its nitro group, which can act as a strong oxidizing agent in certain reactions. N-Methyl-4-Nitro-Benzamide is also used as a reagent in organic synthesis and as a precursor to various other chemicals. It should be handled with care due to its potential reactivity and toxicity.

InChI:InChI=1/C8H8N2O3/c1-9-8(11)6-2-4-7(5-3-6)10(12)13/h2-5H,1H3,(H,9,11)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 74-89-5 methylamine 
• 108-24-7 acetic anhydride 
• 16089-71-7 N-(p-nitrobenzylidene)methylamine N-oxide 
• 877-80-5 N-methyl-4-nitrobenzylideneamine 
• 1092-52-0 N-(4-methoxyphenyl)-N-methyl-4-nitrobenzamide 
• 593-51-1 methylamine hydrochloride 
• 134814-87-2 Benzoic acid [methyl-(4-nitro-benzoyl)-amino]-methyl ester 
• 68823-17-6 3-methyl-2-(4-nitro-phenyl)-4,6-dioxo-5-phenyl-5,6-dihydro-4H-[1,3]oxazinium betaine 
• 84-11-7 9,10-phenanthrenequinone 
• 3400-27-9 2-methyl-3-p-nitrophenyloxaziridine 
• 421-20-5 Methyl fluorosulfonate 
• 619-72-7 4-nitrobenzonitrile 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 20743-51-5 1-methyl-5-(4-nitrophenyl)-1H-tetrazole 
• 1144-74-7 4-nitrobenzophenone 
• 20857-92-5 N-(p-nitrobenzoyl)azacyclohexane 
• 38681-76-4 N-isopropyl-4-nitrobenzamide 
• 7506-46-9 N-cyclohexyl-4-nitrobenzamide 
• 89399-21-3 N-hexyl-4-nitrobenzamide 
• 2585-26-4 4-nitro-N-benzylbenzamide 
• 1439356-98-5 ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate 
• 1166974-87-3 N-methyl-5-nitro-[1,1'-biphenyl]-2-carboxamide 
• 66124-26-3 N,N'-Dimethyl-4-nitrobenzamidine 
• 66124-29-6 N,N'-Dimethyl-N-(2,4-dinitro)phenyl-(4-nitro)benzamidine 
• 62-23-7 4-nitro-benzoic acid 
• 59476-41-4 N-Methyl-N,4-dinitrobenzamide 
• 134814-87-2 Benzoic acid [methyl-(4-nitro-benzoyl)-amino]-methyl ester 

Relevant articles and documents

Trifluoroacetic Acid Hydroxylamine System as Organocatalyst Reagent in a One-Pot Salt Free Process for the Synthesis of Caprolactam and Amides of Industrial Interest

In this work we studied the reactivity of the Trifluoroacetic acid hydroxylamine system in the one step salt free synthesis of amides from ketones. A particular regards was paid to the caprolactam synthesis because of its industrial relevance. Synthesis, reactivity and characterization of the hydroxylamine trifluoroacetate is given. Fast oximation reaction of several ketones was gained at room temperature (1?h of reaction quantitative conversion for several ketones). In the same reactor, by raising the temperature at 383?K, the Beckmann rearrangement of the so obtained oximes is easily accomplished in the presence of three equivalent of TFA. The possibility of obtaining the trifluoroacetate of the hydroxylamine with a modified nitric acid hydrogenation reactions was verified, too. Reuse of solvent and trifluoroacetic acid is easily achieved by distillation. Graphical abstract: Salt free one-pot caprolactam and amides process catalyzed by CF3COOH, in the presence of NH2OH TFA as the oximation agent.[Figure not available: see fulltext.].

2-(4-methanoyl) anilino-4-aminopyrimidine derivatives and application thereof

The invention belongs to the technical field of chemical medicines, and particularly relates to 2-(4-methanoyl) anilino-4-aminopyrimidine derivatives and application thereof. According to the invention, nitryl, carboxyl, cyano and the like are adopted to

4, 6-disubstituted pyridine [3, 2-d] pyrimidine compound as well as preparation and application thereof

The invention belongs to the technical field of medicines. The invention relates to the field of pharmaceutical chemistry, in particular to a 4, 6-disubstituted pyridine [3, 2-d] pyrimidine compound and pharmaceutically acceptable salt thereof, a preparation method of the compound, a pharmaceutical composition taking the compound as an active ingredient, and application of the compound in preparation of an MNK inhibitor and drugs for treating and/or preventing various cancers and/or metabolic diseases. The present invention relates to compounds represented by formulas I, II, III or IV, and pharmaceutically acceptable salts, hydrates, solvates and metabolites thereof, wherein the variables are described in the claims and the description.