2595-97-3Relevant articles and documents
New 3,4-seco-diterpene and coumarin derivative from the leaves of Trigonostemon flavidus Gagnep
Ban, Ninh Khac,Linh, Tran My,Mai, Nguyen Chi,Tai, Bui Huu,Nhiem, Nguyen Xuan,Hoang, Nguyen Huy,Kiem, Phan Van
, p. 3247 - 3254 (2022)
Two new compounds named trigoflavidus A (1) and trigoflavidus B (2), and eight known compounds, trigoflavidone (3), heterophypene (4), howpene C (5), 3,4-seco-sonderianol (6), trigonochinene C (7), fraxidin (8), isofraxidin (9), and isofraxetin (10) were isolated from the leaves of Trigonostemon flavidus Gagnep. by various chromatographic methods. Their chemical structures were elucidated via UV, IR, HR-ESI-MS and NMR spectroscopic methods and divided into two groups including six 3,4-seco-diterpenes (1, 3-7) and four coumarins (2, 8-10). Absolute configurations at stereocenters of compound 1 were confirmed by comparison of its CD spectra with those of the TD-DFT calculations. At a concentration of 30 μM, compounds 1–10 exhibited weak cytotoxic activity toward LU1, HepG2, MCF7, and SKMel2 human cell lines (cell viability all over 50%).
Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
Kim, Young Ho,Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Ha, Le Minh,Tai, Bui Huu,Quang, Tran Hong,Tung, Nguyen Huu
, p. 392 - 396 (2010)
The chemical study of Momordica charantia fruits led to the isolation of three new cucurbitane triterpene glycosides, momordicosides U, V, and W (1-3). The structures of these compounds were determined to be (19R,23R)-5β, 19-epoxy-19-methoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D- allopyranoside (1), (23R)-5β, 19-epoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (2), and (19R)-5β, 19-epoxy-19,25- dihydroxycucurbita-6,23(E)-diene-3β-ol 3-O-β-D-glucopyranoside (3), by chemical and spectroscopic methods.
Acute and sub-chronic toxicity of D-allose in rats
Iga, Yusuke,Nakamichi, Kazunori,Shirai, Yoko,Matsuo, Tatsuhiro
, p. 1476 - 1478 (2010)
We examined the acute and sub-chronic toxicity of D-allose in rats. In the acute toxicity test, the calculated LD50 value was 20.5 g/kg. In the sub-chronic toxicity test, no difference was found among the four groups in most of the serum chemical and hematological test results. These results suggest that D-allose is not toxic to rats.
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Pratt,Richtmyer
, p. 1906 (1955)
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Phenolic glycosides from the Chinese liverwort reboulia hemisphaerica
Wang, Li-Ning,Guo, Dong-Xiao,Wang, Shu-Qi,Wu, Chang-Sheng,Rehman, Mujeeb Ur,Lou, Hong-Xiang
, p. 1146 - 1152 (2011)
Four new phenolic glycosides, named rebouosides A-D (1-4, resp.), along with three known ones 2-(3,4-dihydroxyphenyl)ethyl 2-O-α-L- rhamnopyranosyl-β-D-allopyranoside (5), 2-(3,4-dihydroxyphenyl)ethyl β-D-allopyranoside (6), 2-(3,4-dihydroxyphenyl)ethyl β-D- glucopyranoside (7), and a nucleoside, inosine (8), were isolated from Chinese liverwort Reboulia hemisphaerica. Their structures were elucidated by acidic hydrolysis and extensive spectroscopic methods, including 2D-NMR techniques.
HPLC-ESIMSn profiling, isolation, structural elucidation, and evaluation of the antioxidant potential of phenolics from Paepalanthus geniculatus
Pereira Do Amaral, Fabiano,Napolitano, Assunta,Masullo, Milena,Campaner Dos Santos, Lourdes,Festa, Michela,Vilegas, Wagner,Pizza, Cosimo,Piacente, Sonia
, p. 547 - 556 (2012)
The methanol extract of the flowers of Paepalanthus geniculatus Kunth. showed radical-scavenging activity in the TEAC assay. An analytical approach based on HPLC-ESIMSn was applied to obtain the metabolite profile of this extract and led to the rapid identification of 19 polyphenolic compounds comprising flavonoids and naphthopyranones. The new naphthopyranone (10, 16), quercetagetin (1, 5, 7, 13), and galetine derivatives (9, 11, 17, 19), and a flavonol glucoside cyclodimer in the truxillate form (12), were identified. Compounds 2, 6, and 7 showed the highest antioxidant capacity and ability to affect the levels of intracellular ROS in human prostate cancer cells (PC3).
α-Glucosidase inhibition properties of cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Tung, Nguyen Huu,Ha, Le Minh,Ha, Do Thi,Tai, Bui Huu,Quang, Tran Hong,Ngoc, Tran Minh,Kwon, Young-In,Jang, Hae-Dong,Kim, Young Ho
, p. 720 - 724 (2010)
Fourteen cucurbitane-type triterpene glycosides (1-14) were isolated from a methanol extract of Momordica charantia fruits, including three new compounds, charantosides A-C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for α-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against α-glucosidase. Whereas, 2, 3, 6-11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.
Anti-inflammatory active components of the roots of Datura metel
Qin, Ze,Zhang, Jin,Chen, Liang,Liu, Shu-Xiang,Zhao, Hai-Feng,Mao, Hui-Min,Zhang, Hong-Yang,Li, De-Fang
, p. 392 - 398 (2020/03/30)
One new phenolic glycoside, methyl 3,4-dihydroxyphenylacetate-4-O-[2-O-β-D-apisoyl-6-O-(2-hydroxybenzoyl)]-β-D-glucopyranoside (1), together with 10 known compounds (2–11), were isolated from the roots of Datura metel. The structures of these compounds we
Method for preparing lactic acid through catalytically converting carbohydrate
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Paragraph 0029-0040, (2020/11/01)
The invention relates to a method for preparing lactic acid through catalytically converting carbohydrate, and in particular, relates to a process for preparing lactic acid by catalytically convertingcarbohydrate under hydrothermal conditions. The method disclosed by the invention is characterized by specifically comprising the following steps: 1) adding carbohydrate and a catalyst into a closedhigh-pressure reaction kettle, and then adding pure water for mixing; 2) introducing nitrogen into the high-pressure reaction kettle to discharge air, introducing nitrogen of 2 MPa, stirring and heating to 160-300 DEG C, and carrying out reaction for 10-120 minutes; 3) putting the high-pressure reaction kettle in an ice-water bath, and cooling to room temperature; and 4) filtering the solution through a microporous filtering membrane to obtain the target product. The method can realize high conversion rate of carbohydrate and high yield of lactic acid, and has the advantages of less catalyst consumption, good circularity, small corrosion to reaction equipment and the like.