272104-64-0

Basic information

• Product Name: 4-Quinolinecarboxylic acid, 3-(bromomethyl)-2-phenyl-, methyl ester
• CAS NO: 272104-64-0
• Molecular Formula: C18H14BrNO2
• Molecular Weight: 356.219
• Mol File: 272104-64-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-Quinolinecarboxylic acid, 3-(bromomethyl)-2-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinolinecarboxylic acid, 3-(bromomethyl)-2-phenyl-, methyl ester(272104-64-0)
• EPA Substance Registry System: 4-Quinolinecarboxylic acid, 3-(bromomethyl)-2-phenyl-, methyl ester(272104-64-0)

Safety Data

• Hazardous Substances Data: 272104-64-0(Hazardous Substances Data)

Upstream product

• 74960-43-3 3-methyl-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 94-36-0 dibenzoyl peroxide 
• 93-55-0 1-phenyl-propan-1-one 
• 91-56-5 indole-2,3-dione 
• 174636-71-6 3-methyl-2-phenylquinoline-4-carbonyl chloride 
• 43071-45-0 3-methyl-2-phenylquinoline-4-carboxylic acid 

Downstream Products

• 345235-08-7 3-(4-cyclohexyl-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 270574-03-3 3-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoline-4-Carboxylic Acid Methyl Ester 
• 345235-10-1 3-(4-morpholin-4-yl-piperidin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 1336960-15-6 3-(1,4'-bipiperidin-1'-ylmethyl)-2-phenyl-N-(1-phenylcyclopropyl)-4-quinolinecarboxamide 
• 930577-45-0 C₂₇H₂₆N₂OS 
• 1205002-49-8 C₁₈H₁₅NO₂S 
• 887396-96-5 methyl 3-[({[(2S)-1-methyl-2-pyrrolidinyl]methyl}oxy)methyl]-2-phenyl-4-quinolinecarboxylate 
• 887400-54-6 methyl 3-((acetyl(methyl)amino)methyl)-2-phenyl-4-quinolinecarboxylate 
• 941691-13-0 methyl 3-(azidomethyl)-2-phenylquinoline-4-carboxylate 
• 916481-59-9 methyl 3-(cyanomethyl)-2-phenylquinoline-4-carboxylate 
• 887397-06-0 methyl 3-({[((2S)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-2-pyrrolidinyl)methyl]oxy}methyl)-2-phenyl-4-quinolinecarboxylate 
• 887330-06-5 methyl 3-(2-oxo-1-pyrrolidinyl)methyl-2-phenyl-4-quinolinecarboxylate 
• 345235-03-2 {1-[4-((S)-1-Cyclohexyl-ethylcarbamoyl)-2-phenyl-quinolin-3-ylmethyl]-piperidin-4-yl}-carbamic Acid 9H-fluoren-9-ylmethyl Ester 
• 270574-13-5 3-(4-Fmoc-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic Acid ((S)-1-cyclohexyl-ethyl)-amide 

Relevant articles and documents

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4

Transient Receptor Potential Vanilloid 4 (TRPV4) is a member of the Transient Receptor Potential (TRP) superfamily of cation channels. TRPV4 is expressed in the vascular endothelium in the lung and regulates the integrity of the alveolar septal barrier. Increased pulmonary vascular pressure evokes TRPV4-dependent pulmonary edema, and therefore, inhibition of TRPV4 represents a novel approach for the treatment of pulmonary edema associated with conditions such as congestive heart failure. Herein we report the discovery of an orally active, potent, and selective TRPV4 blocker, 3-(1,4′-bipiperidin-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide (GSK2193874, 28) after addressing an unexpected off-target cardiovascular liability observed from in vivo studies. GSK2193874 is a selective tool for elucidating TRPV4 biology both in vitro and in vivo.

Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Certain compounds of formula (I) below or a pharmaceutically acceptable salt or hydrate thereof: (I) wherein: R1 is H or C1-6 alkyl; R2 is aryl or C3-7 cycloalkyl or heteroaryl; R3 is H or C1-3

Quinoline derivatives as NK-2 and NK-3 receptor ligands

A compound, or a solvate or a salt thereof, of formula (I): wherein R is linear or branched alkyl; R1represents hydrogen or up to four optional substituents selected from the list consisting of: C1-6alkyl, C1-6alkenyl, ary