2729-19-3

Basic information

• Product Name: Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-
• Synonyms: 2-(4-Fluoro-phenyl)-1-(4-methoxy-phenyl)-ethanone;2-(4-fluorophenyl)-1-(4-methoxyphenyl)ethanone;(p-fluorobenzyl)(p-methoxyphenyl)ketone;4'-fluoro-4-methoxy-deoxybenzoin;4'-Fluor-4-methoxy-desoxybenzoin
• CAS NO: 2729-19-3
• Molecular Formula: C15H13FO2
• Molecular Weight: 244.265
• Mol File: 2729-19-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 106 - 108 °C (cyclohexane)
• Boiling Point: 197-202 °C(Press: 7 Torr)
• Density: 1.163±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-(2729-19-3)
• EPA Substance Registry System: Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-(2729-19-3)

Safety Data

• Hazardous Substances Data: 2729-19-3(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)- is a chemical compound with the molecular formula C16H13FO2. It is a ketone compound that contains a fluorine-substituted phenyl group and a methoxy-substituted phenyl group. Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)- is a member of the chalcone family, which are precursors to flavonoids. It has potential applications in pharmaceuticals, agrochemicals, and materials science due to its diverse chemical properties and potential for biological activity. Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)- may be used in organic synthesis and medicinal chemistry for the development of new drugs and therapeutic agents.

Upstream product

• 100-66-3 methoxybenzene 
• 405-50-5 p-Fluorophenylacetic acid 
• 21382-98-9 p-cyanophenyl methyl sulfide 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-04-1 4-Fluorophenylacetyl chloride 

Downstream Products

• 1650-46-0 2-(4-fluoro-phenyl)-1,1-bis-(4-methoxy-phenyl)-ethene 
• 1446909-36-9 5-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-methyl-1H-imidazole-2(3H)-thione 
• 1446909-42-7 5-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-methyl-2-(methylthio)-1H-imidazole 
• 1455272-74-8 4-(4-methoxyphenyl)-5-(4-fluorophenyl)-2-(methylthio)-thiazole 
• 1455272-76-0 4-(4-methoxyphenyl)-5-(4-fluorophenyl)-2-(benzylthio)-thiazole 
• 456-22-4 4-Fluorobenzoic acid 
• 100-09-4 4-methoxybenzoic acid 
• 97059-78-4 5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide 
• 97059-72-8 5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 

Relevant articles and documents

An Oxidant- And Catalyst-Free Synthesis of Dibenzo[ a, c ]carbazoles via UV Light Irradiation of 2,3-Diphenyl-1 H -indoles

An efficient methodology for the synthesis of dibenzo[a,c]- carbazoles via annulation of 2,3-diphenyl-1H-indoles in EtOH under UV light irradiation (λO = 365 nm) along with hydrogen evolution is described. This method exhibits the advantages of mild reaction conditions, no requirement of any oxidants and catalysts, and release of hydrogen as the only byproduct. Notably, the mechanism investigation confirms that the trans-4b,8a-dihydro-9H-dibenzo[a,c]carbazole intermediate could convert into cis-4b,8a-dihydro-9H-dibenzo[a,c]carbazole, which relies on the nitrogen atom of the indole ring. This is followed by intramolecular dehydrogenation which yields the dibenzo[a,c]carbazoles. 2021. Thieme. All rights reserved.

Synthesis and antiseizure activity of (E)-1,2-diarylethylidenehydrazine carboximidamides against tonic-clonic seizures: an intracerebroventricular and electrophysiological study

A series of (E)-1,2-diarylethylidenehydrazine carboximidamides 2a–j were synthesized and characterized by NOESY experiment as anticonvulsant agents and their antiseizure activity was evaluated by intracerebroventricular administration of compounds. Most of the compounds had significant protection against tonic-clonic seizures and 2a was found to be as equipotent as carbamazepine in seizures control. In order to find their anticonvulsant mechanism of action, 2a was subjected to further electrophysiological studies using patch-clamp technique. The results confirmed that this compound is neither a voltage-gated sodium channel blocker nor a NMDA/AMPA antagonist. Although 2a did not show any direct GABA agonistic activity, it could decrease EPSP and increase IPSP frequency without any change in amplitude. Finally, the results indicated most likely a presynaptic GABA-mediated mechanism of 2a for its antiseizure activity such as inhibition of the GABA-T which was validated by molecular docking.

Synthesis of substituted phenanthrofurans

A three-step protocol toward phenanthrofurans 1 starting with deoxybenzoins 3 is developed with moderate to good yield. A facile process is carried out for the (1) α-propargylation of 3 with NaH and propargyl bromide 2 in refluxing THF, (2) Bi(OTf)3-mediated cycloisomerization of γ-ynones 4 with 4 ? molecular sieves in MeNO2 at rt, and (3) photolytic Scholl annulation of 2,3-diarylfurans 5 with I2 in EtOAc at rt. The key structures of 1 are confirmed by X-ray crystallographic analysis.