273738-38-8Relevant articles and documents
Enantioselective total synthesis of (+)-scyphostatin, a potent and specific inhibitor of neutral sphingomyelinase
Inoue, Munenori,Yokota, Wakako,Katoh, Tadashi
, p. 622 - 637 (2008/01/04)
The total synthesis of (+)-scyphostatin, a specific and potent neutral sphingomyelinase inhibitor from a microorganism, was accomplished for the first time starting from D-arabinose and both enantiomers of methyl 3-hydroxy-2-methylpropionate. The method i
Synthesis (and alternative proof of configuration) of the scyphostatin C(1')-C(20') trienoyl fragment.
Hoye,Tennakoon
, p. 1481 - 1483 (2007/10/03)
[reaction--see text] Each of four diastereomers of structure 2, corresponding to the lipophilic side chain of scyphostatin (1), were prepared. Careful analysis of their NMR spectral data and comparison with those of the natural product corroborates the re