28734-00-1 Usage
Description
4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE, also known as PIK-75, is a chemical compound with the molecular formula C21H18N4. It is a potent inhibitor of phosphatidylinositol 4-kinase (PI4K) and has been shown to possess anti-cancer properties. PIK-75 has been studied for its potential in inhibiting tumor growth and metastasis in various types of cancer, including breast and lung cancer. It is also being researched for its potential in combination therapy with other anticancer agents. Furthermore, PIK-75 has been found to have neuroprotective effects and is being investigated for its potential in treating neurodegenerative diseases. Overall, PIK-75 is a versatile compound with promising therapeutic potential in the fields of oncology and neurology.
Uses
Used in Oncology:
4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE is used as an anti-cancer agent for its potential in inhibiting tumor growth and metastasis in various types of cancer, such as breast and lung cancer. It functions as a potent inhibitor of phosphatidylinositol 4-kinase (PI4K), which plays a crucial role in cancer cell proliferation and survival.
Used in Combination Therapy:
4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE is used as a component in combination therapy with other anticancer agents to enhance the overall therapeutic effect and potentially overcome drug resistance in cancer treatment.
Used in Neurology:
4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE is used as a neuroprotective agent for its potential in treating neurodegenerative diseases. Its neuroprotective effects are currently being investigated, offering hope for the development of new treatments for such conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 28734-00-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,7,3 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 28734-00:
(7*2)+(6*8)+(5*7)+(4*3)+(3*4)+(2*0)+(1*0)=121
121 % 10 = 1
So 28734-00-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H14N4/c17-16-19-15(14-9-5-2-6-10-14)12-20(16)18-11-13-7-3-1-4-8-13/h1-12H,(H2,17,19)/b18-11+
28734-00-1Relevant articles and documents
Cascade cyclization of 1,2-diamino-4-phenylimidazole with aromatic aldehydes and cyclohexanediones
Lipson,Svetlichnaya,Shirobokov,Musatov,Shishkin,Shishkina
supporting information; experimental part, p. 273 - 277 (2012/05/21)
The three-component condensation of 1,2-diamino-4-phenylimidazole with aromatic aldehydes and 1,3-cyclohexanediones occurred regioselectively and afforded 3-amino-1-phenyl-10-aryl-7,8-dihydroimidazo[1,5-b] cinnolin-9(5H,6H, 10H)-ones. Pleiades Publishing, Ltd., 2012.
Synthesis of dihydro derivatives of 2-amino-4,5,7-triarylimidazo[1,5-b]pyridazine
Kolos,Orlov,Paponov,Shishkin
, p. 1207 - 1213 (2007/10/03)
7-Amino-2,4,5-triaryl-3,4-dihydroimidazo[1,5-b]pyridazines have been synthesized by reacting 4-aryl-1,2-diaminoimidazoles with 1,3-diarylpropenones. The structure of one of the products was confirmed by X-ray structural analysis. 1999 Kluwer Academic/Plen