306-37-6 Usage
Description
1,2-Dimethylhydrazine dihydrochloride, also known as 1,2-dimethylhydrazine hydrochloride, is a chemical compound with the formula C2H8N2·2HCl. It is a white crystalline powder or prisms that exhibit a distinct amine fishy or ammonia-like odor. 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE is a hydrochloride resulting from the reaction of 1,2-dimethylhydrazine with 2 mol eq. of hydrogen chloride.
Uses
1,2-Dimethylhydrazine dihydrochloride is used as a potent carcinogen for [application type] in [application reason] as a DNA alkylating agent. It is particularly utilized to induce colon tumors in experimental animals, which aids in the study and understanding of cancer development and progression.
Used in Pharmaceutical Industry:
1,2-Dimethylhydrazine dihydrochloride is used as a reagent for the preparation of spiroisoquinolinedione aldose reductase inhibitors. These inhibitors are essential in the development of drugs targeting various diseases and conditions, including diabetes and its complications.
Used in Research and Development:
In the field of research and development, 1,2-dimethylhydrazine dihydrochloride is used as a tool to study the effects of carcinogens on DNA and cellular processes. This helps scientists understand the mechanisms behind cancer development and design more effective treatments and preventive measures.
Air & Water Reactions
Extremely hygroscopic. Water soluble.
Reactivity Profile
1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE is a reducing agent. Incompatible with oxidizing agents and bases.
Fire Hazard
Flash point data for 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE are not available; however, 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE is probably combustible.
Biochem/physiol Actions
Induces colon cancer in rats and mice.
Safety Profile
Suspected carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by ingestion and subcutaneous routes.
Experimental reproductive effects. Mutation
data reported. A rocket fuel. When heated to
decomposition it emits very toxic fumes of
HCl and NOx
Check Digit Verification of cas no
The CAS Registry Mumber 306-37-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 306-37:
(5*3)+(4*0)+(3*6)+(2*3)+(1*7)=46
46 % 10 = 6
So 306-37-6 is a valid CAS Registry Number.
InChI:InChI=1/C2H8N2.2ClH/c1-4(2)3;;/h3H2,1-2H3;2*1H
306-37-6Relevant articles and documents
Stabilization of Azapeptides by Namide···H-NamideHydrogen Bonds
Baruah, Kalpita,Sahariah, Biswajit,Sakpal, Sushil S.,Deka, Jugal Kishore Rai,Bar, Arun Kumar,Bagchi, Sayan,Sarma, Bani Kanta
supporting information, p. 4949 - 4954 (2021/06/28)
An unusual Namide···H-Namide hydrogen bond (HB) was previously proposed to stabilize the azapeptide β-Turns. Herein we provide experimental evidence for the Namide···H-Namide HB and show that this HB endows a stabilization of 1-3 kcal·mol-1 and enforces the trans-cis-Trans (t-c-T) and cis-cis-Trans (c-c-T) amide bond conformations in azapeptides and N-methyl-Azapeptides, respectively. Our results indicate that these Namide···H-Namide HBs can have stabilizing contributions even in short azapeptides that cannot fold to form β-Turns.