306278-24-0

Basic information

• Product Name: 4-chlorophenyl 2-phenylimidazo[1,2-a]pyridin-3-yl sulfide
• Synonyms: 4-chlorophenyl 2-phenylimidazo[1,2-a]pyridin-3-yl sulfide
• CAS NO: 306278-24-0
• Molecular Formula: C₁₉H₁₃ClN₂S
• Molecular Weight: 336.83792
• Mol File: 306278-24-0.mol
• Article Data: 26

Chemical Properties

• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• PKA: 4.49±0.50(Predicted)
• CAS DataBase Reference: 4-chlorophenyl 2-phenylimidazo[1,2-a]pyridin-3-yl sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorophenyl 2-phenylimidazo[1,2-a]pyridin-3-yl sulfide(306278-24-0)
• EPA Substance Registry System: 4-chlorophenyl 2-phenylimidazo[1,2-a]pyridin-3-yl sulfide(306278-24-0)

Safety Data

• Hazardous Substances Data: 306278-24-0(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 98-86-2 acetophenone 
• 106-54-7 p-Chlorothiophenol 
• 2751-25-9 p-chlorophenylsulfonyl hydrazide 
• 7205-80-3 1-(ethylsulfonyl)-4-chlorobenzene 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 1146-44-7 4,4'-dichlorophenyl thiosulfonate 
• 100-03-8 4-chlorobenzenesulfinic acid 
• 1213-40-7 S-(4-chlorophenyl)benzene thiosulfonate 
• 70-11-1 α-bromoacetophenone 
• 1679-18-1 4-Chlorophenylboronic acid 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 

Relevant articles and documents

Design, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles

We report herein, the design, synthesis and study of anticancer properties of sulfenylated 2-phenylimidazo[1,2-a]pyridines and their analogues. A set of twenty sulfenylated imidazo[1, 2-a]pyridine derivatives were synthesized. Whereby elusive amendments to the imidazo[1,2-a]pyridine motif confer dramatic changes in functional affinity of a novel action to modulate anticancer activity in seven different human cancer cell lines i.e.: MDA MB 231 (breast), HepG2 (liver), Hela (cervical), A549 (lung), U87MG (glioblastoma), SKMEL-28 (skin melanoma) and DU-145 (prostate) by employing MTT assay. Among the series, compounds 4e (naphthalene), 4f (styrene) and 4h (thiomethyl) showed potent activity towards human liver cancer cells HepG2. Cell cycle analysis results revealed that these compounds arrested the cell cycle at G2/M phase and induced apoptosis in human liver cancer cells HepG2. It was further confirmed by Hoechst staining, Measurement of mitochondrial membrane potential (ΔΨm) and Annexin V-FITC assay.

One-pot synthesis of imidazo[1,2-α]pyridine thioethers using imidazo[1,2-α]pyridines, arylsulfonyl chlorides and hydrazine

A one-pot reaction of making RS-substituted imidazo[1,2-α]pyridine derivatives by directly using aryl or alkylsulfonyl chloride and hydrazine was developed, selectively giving good yields of the expected products. Compared with previously reported methods

Electrochemical Oxidative C—H Sulfenylation of Imidazopyridines with Hydrogen Evolution

Selective oxidative C—H sulfenylation of imidazopyridine heterocycles is achieved using an undivided electrolytic cell. The reaction avoids the use of stoichiometric amount of external chemical oxidant and produces hydrogen gas as the only byproduct. Both