3068-00-6Relevant articles and documents
A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa
Yamashita, Takahiro,Nakao, Yoichi,Matsunaga, Shigeki,Oikawa, Tsutomu,Imahara, Yukimitsu,Fusetani, Nobuhiro
, p. 2181 - 2184 (2009)
A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-H
Ru/SiO2 Catalyst for Highly Selective Hydrogenation of Dimethyl Malate to 1,2,4-Butanetriol at Low Temperatures in Aqueous Solvent
Chen, Can,Jiang, Junxiang,Li, Guangci,Li, Xuebing,Wang, Da,Wang, Zhong,Yu, Pei
, (2022/01/12)
Catalytic selective hydrogenation of esterified malic acid to produce 1,2,4-butanetriol (1,2,4-BT) using H2 as the reducing reagent suffers from the low 1,2,4-BT selectivity. Here, Ru/SiO2 catalyst was employed for selective hydrogenation of dimethyl malate (DM) to produce 1,2,4-BT, which gave abnormal high DM conversion (100%) and 1,2,4-BT selectivity (92.4%) in aqueous solvent at 363?K, especially, the 1,2,4-BT yield even is higher than the optimal catalyst reported (Ru-Re, 79.8%). The reaction pathways for the DM hydrogenation on Ru/SiO2 were also proposed, suggesting that extremely high 1,2,4-BT selectivity require for the much high hydrogenation rates at low temperatures, where side-reaction transesterification rates are relatively low. The extremely high hydrogenation activity and 1,2,4-BT selectivity on Ru/SiO2 in aqueous solvent at low temperatures arise from that H2O may coordinate to Ru2+ and prevent the reduction of Ru2+ to Ru under high H2 pressure. Ru/SiO2 surface presents abundant Ru2+ in aqueous solvent, can activate H2 through heterolytic cleavage mode to form hydride, which can significantly increase hydrogenation rates of C = O groups at low temperatures. In addition, the activity and 1,2,4-BT selectivity on Ru/SiO2 catalyst only reduced by 2.3% and 2.6%, respectively over a period of 550?h. Graphical Abstract: [Figure not available: see fulltext.]
Method for producing 1,2,4-butanetriol
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Paragraph 0038; 0041-0052; 0054-0063, (2020/01/12)
The invention provides a method for producing 1,2,4-butanetriol. According to the method, a reaction of 2-butene-1,4-diol and hydrogen peroxide is catalyzed by a tungstate and secondary amine to generate 2,3-epoxy-1,4-butanediol; an epoxy reaction solution is treated by using catalase and then the epoxy reaction solution is directly used for a hydrogenation reaction without separation and purification; under action of a Raney nickel catalyst, the hydrogenation reaction is carried out by adopting a feeding method of slowly pressing the epoxy reaction solution into a hydrogenation kettle; and astabilizing agent is added in a rectification process of 1,2,4-butanetriol to inhibit side reactions such as oxidation, intramolecular dehydration and the like. Compared with the prior art, the preparation method of the 1,2,4-butanetriol provided by the invention has the advantages that the raw materials are easy to obtain, the reaction is stable and is easy to control, purity of the obtained product is high, and the method is very suitable for industrial production. According to the production method provided by the invention, the content of the obtained product 1,2,4-butanetriol is more than99.5%, the content of sensitive impurity 3-hydroxytetrahydrofuran is less than 0.05%, and the content of aldehydes and ketones is less than 10 [mu]g/mL.