3084-52-4

Basic information

• Product Name: 4H-1,3-Benzoxazin-4-one, 2-phenyl-
• Synonyms: 2-Phenyl-4H-1,3-benzoxazin-4-one;2-phenyl-benzo[e][1,3]oxazin-4-one;2-Phenyl-4H-1,3-benzoxazin-4-on;2-phenyl-4-oxo-1,3-benzoxazine;2-phenyl-benz[e][1,3]oxazin-4-one;2-Phenyl-benz[e][1,3]oxazin-4-on
• CAS NO: 3084-52-4
• Molecular Formula: C14H9NO2
• Molecular Weight: 223.231
• Mol File: 3084-52-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 4H-1,3-Benzoxazin-4-one, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,3-Benzoxazin-4-one, 2-phenyl-(3084-52-4)
• EPA Substance Registry System: 4H-1,3-Benzoxazin-4-one, 2-phenyl-(3084-52-4)

Safety Data

• Hazardous Substances Data: 3084-52-4(Hazardous Substances Data)

Upstream product

• 5663-74-1 N-benzoylsalicylamide 
• 127876-36-2 2-(benzotriazol-1-yl)acetophenone 
• 98-88-4 benzoyl chloride 
• 118-92-3 anthranilic acid 
• 65-85-0 benzoic acid 
• 65-45-2 salicylamide 
• 55-21-0 benzamide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 532-55-8 Benzoyl isothiocyanate 
• 99601-53-3 C₃₂H₂₄NO₃P 
• 99601-64-6 C₂₆H₃₆NO₃P 
• 13316-79-5 O-Benzoylsalicylamide 
• 4578-66-9 o-benzoyloxybenzoic acid 
• 1033079-75-2 2-benzoyloxybenzoyl azide 

Downstream Products

• 1253054-87-3 C₂₀H₁₃N₃O₂ 
• 1253054-93-1 C₂₁H₁₄N₂O₂ 
• 37856-26-1 3-(naphthalen-1-yl)-2-phenylquinazolin-4(3H)-one 
• 37856-17-0 3-(4-methoxyphenyl)-2-phenyl-(3H)-quinazolin-4-one 
• 34280-99-4 3-(4-nitrophenyl)-2-phenylquinazolin-4(3H)-one 
• 22686-82-4 2,3-diphenyl-3H-quinazolin-4-one 
• 37895-88-8 2-phenyl-3-(phenylamino)quinazolin-4(3H)-one 
• 19857-47-7 3-(4-bromophenyl)-2-phenylquinazolin-4(3H)-one 
• 1904-60-5 3-amino-2-phenylquinazolin-4(3H)-one 
• 1218-69-5 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one 
• 201530-41-8 deferasirox 
• 128452-45-9 2-(2-acetoxyphenyl)-4-methylthio-6-phenyl-1,3,5-triazine 
• 14475-26-4 N-salicyloyl-benzamidine 
• 5663-74-1 N-benzoylsalicylamide 

Relevant articles and documents

Preparation of halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones and their transformation into 2-hydroxypyridinyl-substituted 1,2,4-oxadiazoles and 1,2,4-triazoles

A complete study on the preparation of original halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones and their transformation into 1,2,4-oxadiazoles and 1,2,4-triazoles is presented. Starting from pyridyl-imide sodium salts, the efficiency of the intramolecu

Synthesis of 2-(2-Hydroxyaryl)-4H-benzo[e][1,3]oxazin-4-ones by Palladium-Catalyzed C(sp2)?H Hydroxylation via Electro-chemical Oxidation

An electrochemical direct ortho-hydroxylation of 2-aryl-4H-benzo[e][1,3]oxazin-4-ones was developed with Pd(OAc)2 as catalyst, oxazine ring as a directing group and Oxone as the hydroxylation reagent. A series of hydroxylation products were obtained under mild conditions, and the yields were from medium to good. This method is characterized by good functional group tolerance and a wide range of substrates. More importantly, use anodic oxidation to avoid the use of potentially toxic and polluting oxidants. A gram-scale direct electrochemical hydroxylation of 2-phenyl-4H-benzo[e][1,3]oxazin-4-one was performed, and the hydroxylation product was applied to synthesize the drug deferasirox. In addition, the single crystal of 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one was obtained and determined by X-ray diffraction. Finally, the reaction mechanism was proposed and verified by cyclic voltammetry (CV). This protocol also provides an alternative electrochemical hydroxylation methodology for the functionalization of molecules. (Figure presented.).

Chemoselective reaction of benzoylisothiocyanates with hydroxyl group of salicylamide: A new and convenient entry into 2-Aryl-4 H -benzo[e][1,3]oxazin-4- ones

The reactions of benzoylisothiocyanates with salicylamide in pyridine-xylene solution occurs chemoselectively at the hydroxyl group of the salicylamide to afford the corresponding O-benzoyl derivatives. The latter products, on prolonged heating in pyridin