30935-14-9

Basic information

• Product Name: 1,2-diphenylbutane-1,2-diol
• CAS NO: 30935-14-9
• Molecular Formula: C₁₆H₁₈O₂
• Molecular Weight: 242.3129
• Mol File: 30935-14-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 395.3°C at 760 mmHg
• Flash Point: 185.9°C
• Density: 1.139g/cm³
• Vapor Pressure: 5.86E-07mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 1,2-diphenylbutane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-diphenylbutane-1,2-diol(30935-14-9)
• EPA Substance Registry System: 1,2-diphenylbutane-1,2-diol(30935-14-9)

Safety Data

• Hazardous Substances Data: 30935-14-9(Hazardous Substances Data)

Usage

Type of compound

Diol (contains two hydroxyl groups)

Structure

Derived from butane with two phenyl groups attached

Applications

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of fragrances
c. Intermediate in the synthesis of other organic compounds

Chiral ligand

Used in asymmetric synthesis

Research

Studied for potential use in the treatment of cancer and other diseases

Toxicity

Low acute toxicity, generally considered safe for various applications

Upstream product

• 10467-10-4 ethylmagnesium iodide 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 925-90-6 ethylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 93-55-0 1-phenyl-propan-1-one 
• 495-71-6 phenacylacetophenone 

Downstream Products

• 16282-16-9 1,2-diphenyl-butan-1-one 
• 6336-52-3 1,1-diphenylbutan-2-one 
• 105539-07-9 2,2-diphenyl-butyraldehyde 
• 27739-61-3 2-hydroxy-1,2-diphenylbutan-1-one 

Relevant articles and documents

Reductive coupling between aromatic aldehydes and ketones or imines by copper catalysis

The copper-catalyzed reductive coupling of two different carbonyl compounds has been achieved. The reaction of aromatic aldehydes and arylketones with a silylboronate in the presence of a catalytic amount of a CuCl-N-heterocyclic carbene (NHC) complex and a stoichiometric amount of alkoxide base yielded cross-coupled 1,2-diol derivatives. A reaction pathway is proposed that involves the catalytic formation of a nucleophilic α-silyloxybenzylcopper(I) species from the aromatic aldehyde and its subsequent coupling with the arylketone. This process was amenable to asymmetric catalysis. This copper catalyst system also enabled the reductive coupling between aromatic aldehydes and imines.