312600-96-7

Basic information

• Product Name: 6-FLUORO-2-METHYLBENZOXAZOLE 97
• Synonyms: 6-FLUORO-2-METHYLBENZOXAZOLE 97;Benzoxazole,6-fluoro-2-methyl-(9CI);6-FLUORO-2-METHYLBENZOXAZOLE 97%
• CAS NO: 312600-96-7
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.14
• Product Categories: HALIDE;Building Blocks;Heterocyclic Building Blocks;Oxazoles;Benzoxazoles;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles
• Mol File: 312600-96-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 204-205 °C(lit.)
• Flash Point: 190 °F
• Appearance: /
• Density: 1.189 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.351mmHg at 25°C
• Refractive Index: n20/D 1.521(lit.)
• CAS DataBase Reference: 6-FLUORO-2-METHYLBENZOXAZOLE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-2-METHYLBENZOXAZOLE 97(312600-96-7)
• EPA Substance Registry System: 6-FLUORO-2-METHYLBENZOXAZOLE 97(312600-96-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 312600-96-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6FNO/c1-5-10-7-3-2-6(9)4-8(7)11-5/h2-4H,1H3

Upstream product

• 1003-98-1 2-bromo-4-fluoroaniline 
• 75-36-5 acetyl chloride 
• 79-24-3 Nitroethane 
• 372-20-3 3-fluorophenol 
• 5078-07-9 6-hydroxy-2-methylbenzoxazole 
• 1445-45-0 Trimethyl orthoacetate 
• 446-36-6 5-fluoro-2-nitrophenol 
• 53981-24-1 2-amino-5-fluorophenol 
• 78-39-7 Triethyl orthoacetate 
• 1247949-34-3 5-fluoro-2-(1-iminoethyl)phenol 

Downstream Products

• 1018467-26-9 3-[4-(carboxymethyl)benzyl]-6-fluoro-2-methyl-1,3-benzoxazol-3-ium bromide 

Relevant articles and documents

ANDROGEN RECEPTOR ANTAGONISTS

Compounds that inhibit the androgen receptor, pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating cancer using such compounds are described.

One-pot synthesis of benzoxazoles via the metal-free ortho-C-H functionalization of phenols with nitroalkanes

PPA-activated nitroalkanes are employed in the design of a one-pot cascade transformation involving metal-free and oxidant-free direct ortho-C-H functionalization, followed by Beckman rearrangement and intramolecular cyclocondensation to produce benzoxazoles and benzobisoxazoles directly from easily available phenols.

PhenoFluorMix: Practical chemoselective deoxyfluorination of phenols

A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.