312624-01-4

Basic information

• Product Name: (S)-(-)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&
• Synonyms: (S)-(-)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&;(S)-4-Methyldiphenyl-2-oxazolidinone;(S)-4-Methyl-3,4-diphenyloxazolidin-2-one;(S)-4-Benzhydryloxazolidin-2-one
• CAS NO: 312624-01-4
• Molecular Formula: C16H15NO2
• Molecular Weight: 253.3
• Product Categories: Asymmetric Synthesis;Chiral Auxiliaries;Oxazolidinone Derivatives
• Mol File: 312624-01-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 144-147 °C(lit.)
• Boiling Point: 472.6 °C at 760 mmHg
• Flash Point: 239.6 °C
• Appearance: /
• Density: 1.181 g/cm³
• Vapor Pressure: 4.22E-09mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-(-)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&(312624-01-4)
• EPA Substance Registry System: (S)-(-)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&(312624-01-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 312624-01-4(Hazardous Substances Data)

Usage

General Description

The chemical compound (S)-(-)-4-(diphenylmethyl)-2-oxazolidin is a chiral oxazolidine derivative with a molecular formula of C18H17NO. It consists of a five-membered ring containing an oxygen and nitrogen atom, and a diphenylmethyl group attached to the nitrogen atom. (S)-(-)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN& is commonly used as a chiral building block in the synthesis of pharmaceuticals and agrochemicals. Its chiral nature makes it valuable in asymmetric synthesis, where specific stereochemical configurations are required. (S)-(-)-4-(diphenylmethyl)-2-oxazolidin is known for its role as a key intermediate in the production of various important organic compounds, making it a versatile and valuable chemical reagent in organic synthesis.

InChI:InChI=1/C16H15NO2/c18-16-17-14(11-19-16)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14-15H,11H2,(H,17,18)/t14-/m1/s1

Upstream product

• 87727-28-4 (S)-2-tert-butyl-dimethyl-silanyloxy propanal 
• 176839-76-2 4-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-oxo-butyric acid methyl ester 
• 74262-56-9 (2R)-2-(tert-butyldimethylsilyloxy)propanal 
• 173604-32-5 (S)-4-(hydroxydiphenylmethyl)oxazolidin-2-one 
• 204851-65-0 (R)-2-Hydroxymethyl-3,3-diphenyl-propionic acid 

Downstream Products

• 183116-86-1 (R)-4-Benzhydryl-3-hexanoyl-oxazolidin-2-one 
• 183116-90-7 (R)-4-Benzhydryl-3-octadecanoyl-oxazolidin-2-one 
• 583826-98-6 (S)-4-Benzhydryl-3-[(E)-3-(3,4-dimethoxy-phenyl)-acryloyl]-oxazolidin-2-one 
• 1253413-37-4 C₂₄H₂₃NO₅ 
• 1417575-40-6 C₁₉H₁₉NO₃ 
• 183253-63-6 (R)-4-Benzhydryl-3-{(R)-2-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-propyl]-octadecanoyl}-oxazolidin-2-one 
• 183253-62-5 (R)-4-Benzhydryl-3-{(R)-2-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-propyl]-hexadecanoyl}-oxazolidin-2-one 
• 183253-61-4 (R)-4-Benzhydryl-3-{(R)-2-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-propyl]-7-methyl-octanoyl}-oxazolidin-2-one 
• 183253-60-3 (R)-4-Benzhydryl-3-{(R)-2-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-propyl]-octanoyl}-oxazolidin-2-one 
• 183253-59-0 (R)-4-Benzhydryl-3-{(R)-2-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-propyl]-hexanoyl}-oxazolidin-2-one 
• 192823-98-6 (R)-4-Benzhydryl-3-{(2S,3S)-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-oxo-tetrahydro-furan-3-carbonyl}-oxazolidin-2-one 
• 192823-94-2 (R)-4-Benzhydryl-3-{(2R,3R)-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-oxo-tetrahydro-furan-3-carbonyl}-oxazolidin-2-one 
• 183116-89-4 (R)-4-Benzhydryl-3-hexadecanoyl-oxazolidin-2-one 
• 183116-88-3 (R)-4-Benzhydryl-3-(7-methyl-octanoyl)-oxazolidin-2-one 

Relevant articles and documents

Synthesis and application of N-3,5-dinitrobenzoyl and C3 symmetric diastereomeric chiral stationary phases

Three diastereomeric chiral compounds, namely, (R,R)-(+)-2-amino-1,2-diphenylethanol, (1S,2R)-(+)-2-amino-1,2-diphenylethanol, and (1R,2R)-(+)-1,2-diphenylethylenediamine were used as starting materials for preparing three N-3,5-dinitrobenzoyl derivative

Preparation of chiral oxazolidin-2-ones and vicinal amino alcohols

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Synthesis of N-BOC-D-Diphenylalanine from L-Serine Methyl Ester Hydrochloride

A convenient six step synthesis of N-BOC-D-diphenylalanine from L-serine methyl ester hydrochloride is described.The preparation of a novel chiral auxiliary, an oxazolidinone derived from D-diphenylalaninol, is also described.