3160-17-6

Basic information

• Product Name: 1-Naphthaleneacetonitrile, 5,6,7,8-tetrahydro-
• Synonyms: 1-Cyanmethyl-5,6,7,8-tetrahydro-naphthalin;5-cyanomethyl-1,2,3,4-tetrahydronaphthalene;5-Cyanmethyl-tetralin;(5,6,7,8-Tetrahydro-[1]naphthyl)-acetonitril;(5,6,7,8-tetrahydro-[1]naphthyl)-acetonitrile;1-NAPHTHALENEACETONITRILE, 5,6,7,8-TETRAHYDRO
• CAS NO: 3160-17-6
• Molecular Formula: C12H13N
• Molecular Weight: 171.242
• Mol File: 3160-17-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Naphthaleneacetonitrile, 5,6,7,8-tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Naphthaleneacetonitrile, 5,6,7,8-tetrahydro-(3160-17-6)
• EPA Substance Registry System: 1-Naphthaleneacetonitrile, 5,6,7,8-tetrahydro-(3160-17-6)

Safety Data

• Hazardous Substances Data: 3160-17-6(Hazardous Substances Data)

Usage

Physical form

White to off-white solid

Solubility

Soluble in organic solvents such as ethanol and acetone

Uses

Synthesis of pharmaceuticals and agrochemicals, potential intermediate in the synthesis of various active pharmaceutical ingredients

Biological activities

Anticonvulsant and antihypertensive activities in animal studies

Safety precautions

May cause irritation to the skin, eyes, and respiratory system if not handled properly.

Upstream product

• 64-17-5 ethanol 
• 17450-62-3 5-(chloromethyl)-1,2,3,4-tetrahydronaphthalene 
• 151-50-8 potassium cyanide 
• 4242-18-6 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid 
• 773837-37-9 sodium cyanide 
• 41790-30-1 (5,6,7,8-tetrahydronaphthalene-1-yl)methanol 
• 12154-63-1 tricarbonyl{(4a,5,6,7,8,8a-η)-1,2,3,4-tetrahydronaphthalene}chromium(0) 
• 99749-00-5 lithioacetonitrile 
• 41828-13-1 5,6,7,8-tetrahydro-naphthalene-1-carbaldehyde 
• 119-64-2 tetralin 
• 143-33-9 sodium cyanide 

Downstream Products

• 776-50-1 (1,2,3,4-tetrahydro-5-naphthyl)acetic acid 

Relevant articles and documents

AZEPANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

PROBLEM TO BE SOLVED: To provide a compound that has 5-HT2C receptor agonist activity and is useful as a therapeutic agent or a preventive agent for stress urinary incontinence. SOLUTION: The present invention provides an azepane derivative represented by the following formula or a pharmaceutically acceptable acid addition salt thereof. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPO&INPIT

Chemistry of the podocarpaceae LXXI. Preparation, structure, and reactions of some (arene)tricarbonylchromium(0) complexes. Crystal structure of α-tricarbonylchromium(0)

Tricarbonylchromium(0) (7), tricarbonylchromium(0) (11) and (benzene)tricarbonylchromium(0) (10) were prepared and examined.Complex 7 was obtained as a mixture of diastereomers, an X-ray structural determination showing that the α-isomer possesses a near eclipsed conformation, in agreement with the conformation in solution deduced from 400 MHz 1H NMR analysis.Carbanions derived from 1,3-dithiane, 2-methyl-1,3-dithiane and 2-(2,2-dimethoxyethyl)-1,3-dithiane (24), and the dianion derived from 2,2'-methylenebis-1,3-dithiane (27) were prepared and brought into reaction with the complexes.Compounds 23 and 33 resulted from regioselective attack on 7 at the site predicted.Treatment with methyl electrophiles of the dithianyl η5-intermediate leading to 22 did not give products of acetyl incorporation.Arene lithiation-electrophilic quenching of 7 gave a mixture of compound 6 and its C(14) regioisomer along with the novel ketone 39 and its C(14) regioisomer.