41790-30-1

Basic information

• Product Name: (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol
• Synonyms: (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol;5,6,7,8-Tetrahydro-1-naphthaleneMethanol;1-NAPHTHALENEMETHANOL, 5,6,7,8-TETRAHYDRO-
• CAS NO: 41790-30-1
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.22826
• Mol File: 41790-30-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol(41790-30-1)
• EPA Substance Registry System: (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol(41790-30-1)

Safety Data

• Hazardous Substances Data: 41790-30-1(Hazardous Substances Data)

Usage

Description

(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol is an organic compound with a unique molecular structure, characterized by a tetrahydronaphthalenyl group attached to a methanol molecule. (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol serves as a versatile intermediate in the synthesis of various complex organic molecules, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol is used as a key intermediate in the synthesis of tricyclic benzazepines, which are known for their affinity towards dopamine D1 and D2 receptors. These benzazepines have potential applications in the development of medications for treating various neurological and psychiatric disorders, such as schizophrenia, Parkinson's disease, and attention deficit hyperactivity disorder (ADHD).
Used in Chemical Synthesis:
In the chemical industry, (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol is utilized as a valuable building block for the synthesis of a wide range of complex organic compounds. Its unique structure allows for further functionalization and modification, making it a useful component in the development of new materials, dyes, and other specialty chemicals.

Upstream product

• 4780-79-4 1-naphthalene methanol 
• 119-64-2 tetralin 
• 74145-11-2 8-hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid 
• 4242-18-6 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid 
• 50-00-0 formaldehyd 
• 41828-13-1 5,6,7,8-tetrahydro-naphthalene-1-carbaldehyde 
• 66-77-3 1-naphthaldehyde 
• 66193-59-7 methyl 1,2,3,4-tetrahydro-5-naphthalenecarboxylate 

Downstream Products

• 3160-17-6 2-(5,6,7,8-tetrahydronaphthalene-1-yl)acetonitrile 
• 4242-18-6 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid 
• 3506-84-1 4-(1-naphthyl)-2-butanone 
• 776-50-1 (1,2,3,4-tetrahydro-5-naphthyl)acetic acid 
• 856198-59-9 (+/-)-Hydroxy-phenyl-(5.6.7.8-tetrahydro-naphthyl-⁽¹⁾)-methan 
• 35310-83-9 phenyl(5,6,7,8-tetrahydronaphthalen-1-yl)methanone 
• 91-20-3 naphthalene 
• 90-12-0 1-Methylnaphthalene 
• 51628-45-6 2-Phenyl-propionic acid 5,6,7,8-tetrahydro-naphthalen-1-ylmethyl ester 

Relevant articles and documents

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bedaquiline is a new drug of the diarylquinoline class that has proven to be clinically effective against drug-resistant tuberculosis, but has a cardiac liability (prolongation of the QT interval) due to its potent inhibition of the cardiac potassium channel protein hERG. Bedaquiline is highly lipophilic and has an extremely long terminal half-life, so has the potential for more-than-desired accumulation in tissues during the relatively long treatment durations required to cure TB. The present work is part of a program that seeks to identify a diarylquinoline that is as potent as bedaquiline against Mycobacterium tuberculosis, with lower lipophilicity, higher clearance, and lower risk for QT prolongation. Previous work led to the identification of compounds with greatly-reduced lipophilicity compounds that retain good anti-tubercular activity in vitro and in mouse models of TB, but has not addressed the hERG blockade. We now present compounds where the C-unit naphthalene is replaced by a 3,5-dialkoxy-4-pyridyl, demonstrate more potent in vitro and in vivo anti-tubercular activity, with greatly attenuated hERG blockade. Two examples of this series are in preclinical development.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Photochemically generated bicyclic ortho-quinodimethanes: Photo- enolization of bicyclic aldehydes and ketones

A photoenolization route to bicyclic ortho-quinodimethanes was investigated. Bicyclic photoenols were trapped in an intermolecular fashion with various dienophiles for the first time. All ortho-quinodimethane precursors were prepared via a selective route commencing with 1-indanol, α- tetralol and 1-benzosuberone. Irradiation afforded the E-photoenols exclusively which were trapped with equal efficiency except that derived from indane-4-carboxaldehyde. This low efficiency has been ascribed to rapid auto- oxidation of the aldehyde to carboxylic acid. The facial selectivity of the reaction between the photoenol from benzosuberan-9-carboxaldehyde and dimethyl fumarate was much lower when compared to the other aldehydes in this study. A distorted diene caused by the presence of the seven membered ring explains these results.