32691-58-0

Basic information

• Product Name: 2-Pyrimidineacetonitrile, 4,6-dimethyl- (8CI,9CI)
• Synonyms: 2-Pyrimidineacetonitrile, 4,6-dimethyl- (8CI,9CI)
• CAS NO: 32691-58-0
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.17716
• Product Categories: PYRIMIDINE
• Mol File: 32691-58-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyrimidineacetonitrile, 4,6-dimethyl- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidineacetonitrile, 4,6-dimethyl- (8CI,9CI)(32691-58-0)
• EPA Substance Registry System: 2-Pyrimidineacetonitrile, 4,6-dimethyl- (8CI,9CI)(32691-58-0)

Safety Data

• Hazardous Substances Data: 32691-58-0(Hazardous Substances Data)

Upstream product

• 90090-75-8 2-(carbamoylmethyl)-4,6-dimethylpyrimidine 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 1224935-98-1 α-cyano-4,6-dimethyl-2-pyrimidineacetic acid tert-butyl ester 
• 123-54-6 acetylacetone 
• 54198-72-0 (4,6-dimethylpyrimidin-2-yl)methanol 
• 1558-17-4 4,6-dimethylpyrimidine 
• 143-33-9 sodium cyanide 
• 74502-83-3 2-(Chloromethyl)-4,6-dimethylpyrimidine 
• 108-24-7 acetic anhydride 
• 84041-07-6 2-Amino-5,7-dimethylisoxazolo<2,3-a>pyrimidinium Chloride 

Downstream Products

• 1258979-67-7 C₂₄H₁₅ClN₂O₄ 
• 1258979-61-1 3-(4-chlorophenoxy)-9-(4,6-dimethylpyrimidin-2-yl)-8-imino-2-methyl-4H,8H-pyrano[2,3-f]chromen-4-one 
• 1258979-63-3 C₂₅H₁₇ClN₂O₅ 
• 1224936-05-3 5-amino-4-(4,6-dimethyl-2-pyrimidinyl)-2,3-dihydro-1-(4-methoxyphenyl)pyrrol-2-one 
• 1224936-04-2 5-amino-1-(4-chlorophenyl)-4-(4,6-dimethyl-2-pyrimidinyl)-2,3-dihydropyrrol-2-one 
• 1224936-06-4 5-amino-4-(4,6-dimethyl-2-pyrimidinyl)-2,3-dihydro-1-(4-methylphenyl)pyrrol-2-one 
• 1224936-02-0 5-amino-4-(4,6-dimethyl-2-pyrimidinyl)-2,3-dihydro-1-phenylpyrrol-2-one 
• 77204-22-9 α-(4,6-dimethyl-2-pyrimidinyl)-β-phenylpropionitrile 
• 783325-61-1 4,6-dimethyl-2-methylaminonicotinonitrile 
• 77204-39-8 2-Benzyl-2-(4,6-dimethyl-pyrimidin-2-yl)-3-phenyl-propionitrile 
• 77204-23-0 α-(4,6-dimethyl-2-pyrimidinyl)cinnamonitrile 

Relevant articles and documents

Investigation of the nucleophilic rearrangement of 2-(cyanomethyl)-1,4,6- trimethylpyrimidinium iodide into 4,6-dimethyl-2-methylaminonicotinic acid nitrile

2-(Cyanomethyl)-1,4,6-trimethylpyrimidinium iodide is rearranged into 4,6-dimethyl-2-methylaminonicotinic acid nitrile by interaction with alcoholic solutions of sodium ethylate, methylamine, and also glycine and β-alanine ethyl esters. This conversion was also observed for the first time for pyrimidinium salts during the process of recording 1H NMR spectra in CD3OD solution containing CD3ONa. After the rearrangement deuterium exchange of the protons of the pyridine ring methyl groups was noted spectrally. It was demonstrated experimentally that for carrying out and completing the recyclization a quantity of nucleophilic reagent must convert the molar equivalent quantity of pyridinium salt.

Synthesis of 3-(pyrimidinyl)pyrrole derivatives

Alkylation of 4,6-dimethyl-2-pyrimidineacetonitrile and 2,6-dimethyl-4-pyrimidineacetonitrile with chloroacetic acid anilides was shown to give 5-amino-4-(4,6-dimethyl-2-pyrimidinyl)-2,3-dihydro-1-arylpyrrol-2-ones and 5-amino-4-(2,6-dimethyl-4-pyrimidiny

Molecular Rearrangements. Synthesis, Stability, and Rearrangements of 2-Imino-2H-isoxazolopyrimidines and 2-Aminoisoxazolopyrimidinium Salts

2-Amino derivatives of isoxazolopyrimidinium salts were prepared by the condensation of 3,5-diaminoisoxazole with acetylacetone and benzoylacetone, respectively.The free base, e.g., 2-amino-2H-isoxazolopyrimidine system, was found to be unst