77204-23-0Relevant articles and documents
Studies on Pyrimidine Derivatives. XX. Synthetic Utility of Hydroxymethylpyrimidines and Related Compounds
Sakamoto, Takao,Tanji, Ken-Ichi,Niitsuma, Setsuko,Ono, Takayasu,Yamanaka, Hiroshi
, p. 3362 - 3368 (2007/10/02)
The conversion of a hydroxymethyl group at the 2- or 4-position of simple pyrimidines to a chloromethyl, cyanomethyl, ethoxycarbonylmethyl, or formyl group is described.Various pyrimidines having an olefinic side chain were also synthesized via Witting reagents derived from chloromethylpyrimidines.Keywords - hydroxymethylation; chloromethylpyrimidine; cyanomethylpyrimidine; pyrimidinecarbaldehyde; Witting reaction