74502-83-3

Basic information

• Product Name: 2-(CHLOROMETHYL)-4,6-DIMETHYLPYRIMIDINE
• Synonyms: 2-(CHLOROMETHYL)-4,6-DIMETHYLPYRIMIDINE;2-(chloromethyl)-4,6-dimethylpyrimidine(SALTDATA: FREE)
• CAS NO: 74502-83-3
• Molecular Formula: C₇H₉ClN₂
• Molecular Weight: 156.61
• Mol File: 74502-83-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 33 °C
• Boiling Point: 215.2 °C at 760 mmHg
• Flash Point: 104.3 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 0.219mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.98±0.30(Predicted)
• CAS DataBase Reference: 2-(CHLOROMETHYL)-4,6-DIMETHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-4,6-DIMETHYLPYRIMIDINE(74502-83-3)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-4,6-DIMETHYLPYRIMIDINE(74502-83-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 74502-83-3(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-4,6-dimethylpyrimidine is a chemical compound often used in the field of chemistry for a variety of applications. As its name indicates, the structure of this compound is representative of a pyrimidine that is chloromethylated and dimethylated. With the CAS registry number 35104-51-5, it is a relatively stable chemical, but can react violently with strong oxidizers. It should be safely stored in a cool, dry place, away from strong acids and food. As with any chemical, humans should avoid direct contact with its solid form or inhaling its gas or vapors.

InChI:InChI=1/C7H9ClN2/c1-5-3-6(2)10-7(4-8)9-5/h3H,4H2,1-2H3

Upstream product

• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 27427-89-0 methyl 4,6-dimethylpyrimidine-2-carboxylate 
• 17759-15-8 4-methoxy-2,6-dimethylpyrimidine 1-oxide 
• 1558-17-4 4,6-dimethylpyrimidine 
• 54198-72-0 (4,6-dimethylpyrimidin-2-yl)methanol 
• 89966-68-7 2,6-dimethyl-4-dimethylaminopyrimidine 1-oxide 
• 56536-48-2 2,4,6-trimethylpyrimidine 1-oxide 

Downstream Products

• 1351764-56-1 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-((4,6-dimethylpyrimidin-2-yl)methoxy)-5-fluoronicotinamide 
• 54198-72-0 (4,6-dimethylpyrimidin-2-yl)methanol 
• 126230-97-5 5,7-Dihydro-2-methylfuro<3,4-b>pyridine 
• 77204-31-0 4,6-dimethyl-2-trans-styrylpyrimidine 
• 77204-39-8 2-Benzyl-2-(4,6-dimethyl-pyrimidin-2-yl)-3-phenyl-propionitrile 
• 77204-23-0 α-(4,6-dimethyl-2-pyrimidinyl)cinnamonitrile 
• 77204-33-2 2-cyclohexylidenemethyl-4,6-dimethylpyrimidine 
• 27427-90-3 4,6-dimethyl-2-pyrimidinecarboxaldehyde 
• 32691-58-0 2-(cyanomethylene)-4,6-dimethylpyrimidine 
• 77204-30-9 (4,6-dimethyl-2-pyrimidinylmethyl)triphenylphosphonium chloride 

Relevant articles and documents

IMIDAZOTRIAZINONE COMPOUNDS

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Studies on Pyrimidine Derivatives. XX. Synthetic Utility of Hydroxymethylpyrimidines and Related Compounds

The conversion of a hydroxymethyl group at the 2- or 4-position of simple pyrimidines to a chloromethyl, cyanomethyl, ethoxycarbonylmethyl, or formyl group is described.Various pyrimidines having an olefinic side chain were also synthesized via Witting reagents derived from chloromethylpyrimidines.Keywords - hydroxymethylation; chloromethylpyrimidine; cyanomethylpyrimidine; pyrimidinecarbaldehyde; Witting reaction