331258-40-3

Basic information

• Product Name: Cyclohexanecarboxylic acid, 1-(benzoylamino)-4-oxo-, methyl ester
• Synonyms: 1-Benzoylamino-4-oxo-cyclohexanecarboxylic acid methyl ester;methyl 1-benzimido-4-oxocyclohexane-1-carboxylate;methyl 4-oxo-1-[(phenylcarbonyl)amino]cyclohexanecarboxylate;1-[N-(benzoyl)amino]-4-cyclohexanon-1-carboxylic acid methyl ester
• CAS NO: 331258-40-3
• Molecular Formula: C15H17NO4
• Molecular Weight: 275.304
• Mol File: 331258-40-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 133 - 134 °C
• Boiling Point: 483.8±45.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Cyclohexanecarboxylic acid, 1-(benzoylamino)-4-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 1-(benzoylamino)-4-oxo-, methyl ester(331258-40-3)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 1-(benzoylamino)-4-oxo-, methyl ester(331258-40-3)

Safety Data

• Hazardous Substances Data: 331258-40-3(Hazardous Substances Data)

Upstream product

• 1239450-42-0 2-benzoylamino-3-methoxy-3-oxo-propanol benzoate 
• 24153-31-9 2-benzoylaminoacrylic acid methyl ester 
• 887245-67-2 methyl 1-amino-4-oxocyclohexanecarboxylate 
• 98-88-4 benzoyl chloride 
• 4507-57-7 methyl 1-aminocyclohexanecarboxylate 
• 2756-85-6 1-aminocyclohexane carboxylic acid 
• 20989-42-8 N-benzoylserine methyl ester 
• 38053-91-7 2-trimethylsilyloxy-1,3-butadiene 
• 10144-46-4 N-benzoyl-L-serine methyl ester 
• 331258-39-0 methyl 1-benzimido-4-oxo-2-cyclohexene-1-carboxylate 

Downstream Products

• 182137-60-6 7-[(benzyloxy)carbonyl]-7-azabicyclo[2.2.1]heptane-1-carboxylic acid 
• 182137-63-9 benzyl 1-(chlorocarbonyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate 
• 1330783-90-8 benzyl 1-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-7-azabicyclo[2.2.1]heptane-7-carboxylate 
• 1330783-91-9 benzyl 1-{6-[1-(tert-butoxycarbonyl)-3-methyl-1H-pyrazol-4-yl]-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl}-7-azabicyclo[2.2.1]heptane-7-carboxylate 
• 331258-41-4 methyl 1-benzimido-c-4-methanesulfonyloxycyclohexane-r-1-carboxylate 
• 331258-42-5 methyl N-benzoyl-7-azabicyclo[2.2.1]heptane-1-carboxylate 
• 936545-59-4 methyl 1-(benzamido)-4-methylenecyclohexanecarboxylate 
• 936545-65-2 1-hydroxymethyl-2-azabicyclo[2.2.2]octane 
• 936545-61-8 C₁₇H₂₃NO₆S 
• 936545-60-7 C₁₆H₂₁NO₄ 

Relevant articles and documents

Bruton's tyrosine kinase inhibitor

The invention relates to a compound with a formula I and a pharmaceutically acceptable salt, a solvent compound, an active metabolite, a polycrystalline compound, an ester, an isomer or a prodrug thereof, a pharmaceutical composition containing the compound in the formula I, and application using the same as a selective Bruton's tyrosine kinase inhibitor to prepare a medicine for preventing or treating heterologous immunity diseases and self immunity diseases or cancers. The formula is shown in the specification.

HETEROCYCLIC COMPOUND

Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging

The radiolabeled non-natural amino acid 1-amino-3-cyclobutane-1-carboxylic acid (ACBC) and its analogs are candidate tumor imaging agents useful for positron emission tomography and single photon emission computed tomography due to their selective affinity for tumor cells. The present invention provides methods for stereo-selective synthesis of syn-ACBC analogs. The disclosed synthetic strategy is reliable and efficient and can be used to synthesize a gram quantity of various syn-isomers of the ACBC analogs, particularly, syn-[18F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC) and syn-[123I]-1-amino-3-iodocyclobutane-1-carboxylic (IACBC) acid analogs.