345578-66-7

Basic information

• Product Name: 2-Imidazolidinone, 4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenyl-, (4R)-
• CAS NO: 345578-66-7
• Molecular Formula: C20H18F6N2O2
• Molecular Weight: 432.366
• Mol File: 345578-66-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Imidazolidinone, 4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenyl-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Imidazolidinone, 4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenyl-, (4R)-(345578-66-7)
• EPA Substance Registry System: 2-Imidazolidinone, 4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenyl-, (4R)-(345578-66-7)

Safety Data

• Hazardous Substances Data: 345578-66-7(Hazardous Substances Data)

Upstream product

• 1156454-52-2 C₂₈H₃₄F₆N₂O₂ 
• 618096-34-7 (S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one 
• 345580-18-9 (S)-2-amino-3-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-N-methyl-2-phenylpropionamide 
• 530441-95-3 (R)-1-(1-(bromomethoxy)ethyl)-3,5-bis(trifluoromethyl)benzene 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 62861-51-2 phenacyl trifluoromethanesulfonate 
• 530441-99-7 2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone 
• 345579-91-1 (S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-5-phenylimidazolidine-2,4-dione 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 

Relevant articles and documents

Cu(I)-catalyzed diamination of disubstituted terminal olefins: An approach to potent NK1 antagonist

This paper describes a diamination process using di-tert-butyldiaziridinone as nitrogen source and CuCl as catalyst. A wide variety of disubstituted terminal olefins can be efficiently diaminated in good yields under mild condition. This diamination proce

Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists

(Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.