34911-51-8

Basic information

• Product Name: 2-Bromo-3'-chloropropiophenone
• Synonyms: 2-BROMO-1-(3-CHLOROPHENYL)-1-PROPANONE;2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE;2-BROMO-3'-CHLOROPROPIOPHENONE;3'-CHLORO-2-BROMOPROPIOPHENONE;3'-Chloro-α-bromopropiophenone;α-BroMo-3-chloropropiophenone;Bupropion 2-BroMo IMpurity;1-Propanone,2-broMo-1-(3-chlorophenyl)-
• CAS NO: 34911-51-8
• Molecular Formula: C₉H₈BrClO
• Molecular Weight: 247.52
• EINECS: 252-282-1
• Product Categories: Aromatics
• Mol File: 34911-51-8.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 295 °C at 760 mmHg
• Flash Point: 132.2 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.532
• Refractive Index: 1.5770
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Soluble in acetonitrile, chloroform, dichloromethane and ethyl a
• CAS DataBase Reference: 2-Bromo-3'-chloropropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3'-chloropropiophenone(34911-51-8)
• EPA Substance Registry System: 2-Bromo-3'-chloropropiophenone(34911-51-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 34911-51-8(Hazardous Substances Data)

Usage

Description

2-Bromo-3'-chloropropiophenone is an organic compound that exists as a yellow oil. It is a derivative of propiophenone, featuring a bromine atom at the 2nd position and a chlorine atom at the 3rd position on the phenyl ring. 2-Bromo-3'-chloropropiophenone is known for its versatile chemical properties, making it a valuable intermediate in various chemical syntheses.

Uses

2-Bromo-3'-chloropropiophenone is used as an important intermediate in the synthesis of various compounds across different industries. Its applications can be categorized as follows:
Used in the Agrochemical Industry:
2-Bromo-3'-chloropropiophenone is used as a key intermediate for the production of agrochemicals. It plays a crucial role in the development of pesticides and other chemicals that help protect crops from pests and diseases, ensuring increased agricultural productivity.
Used in the Pharmaceutical Industry:
In the pharmaceutical sector, 2-Bromo-3'-chloropropiophenone is utilized as a vital building block for the synthesis of various drugs. Its unique chemical structure allows for the creation of new molecules with potential therapeutic applications, contributing to the development of novel medications for various health conditions.
Used in the Dyestuff Industry:
2-Bromo-3'-chloropropiophenone also finds application in the dyestuff industry, where it serves as an intermediate for the production of synthetic dyes. These dyes are used in various applications, including textiles, plastics, and printing inks, to impart color and enhance the visual appeal of products.

Upstream product

• 34841-35-5 3'-chloro-propiophenone 
• 17408-16-1 3'-nitropropiophenone 
• 1197-05-3 1-(3-amino-phenyl)-propan-1-one 
• 26293-11-8 β-methyl-3-chlorostyrene 
• 108-90-7 chlorobenzene 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 1049677-59-9 3‐chloromethcathinone 
• 849797-12-2 (R)-Bupropion hydrochloride 
• 94026-07-0 2-<3-Chlor-anilino>-1-<3-chlor-phenyl>-propanon-(1) 
• 1251851-60-1 2-bromo-1-(3-chlorophenyl)propanol 
• 34841-35-5 3'-chloro-propiophenone 
• 206555-32-0 4-(3-chlorophenyl)-5-methylthiazol-2-amine 

Relevant articles and documents

Microwave-assisted Vilsmeier-Haack synthesis of Pyrazole-4-carbaldehydes

The synthesis of 4-formylpyrazoles using Vilsmeier-Haack reagent is a common protocol in pyrazole chemistry. An efficient microwave-assisted synthesis of 4-formylpyrazoles by employing Vilsmeier-Haack reagent (OPC-VH) derived from phthaloyl dichloride/dimethylformamide has been described. This method offers the advantages of operational simplicity, avoiding the use of POCl3 as toxic reagents and reuse of the by-product in the preparation of phthaloyl dichloride.

A Method for the Catalytic Enantioselective Synthesis of Chiral α-Azido and α-Amino Ketones from Racemic α-Bromo Ketones, and Its Generalization to the Formation of Bonds to C, O, and S

A new and practical method has been developed for the transformation of racemic α-bromo ketones to chiral α-azido and α-amino ketones with high enantioselectivity using phase transfer, ion-pair mediated reactions with a recoverable chiral quaternary salt (10 mol %) as catalyst in fluorobenzene-water. The process has been generalized to a variety of other attachments including of C, O, S, and NHR.

Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server

The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.