350490-15-2

Basic information

• Product Name: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)-
• CAS NO: 350490-15-2
• Molecular Formula: C13H15BrO2
• Molecular Weight: 283.165
• Mol File: 350490-15-2.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)-(350490-15-2)
• EPA Substance Registry System: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)-(350490-15-2)

Safety Data

• Hazardous Substances Data: 350490-15-2(Hazardous Substances Data)

Upstream product

• 873-75-6 4-bromobenzenemethanol 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1200-07-3 trans-4-bromocinnamic acid 
• 75-65-0 tert-butyl alcohol 
• 540-88-5 acetic acid tert-butyl ester 
• 1122-91-4 4-bromo-benzaldehyde 
• 62327-21-3 tert-butyl dimethylphosphonoacetate 
• 1663-39-4 tert-Butyl acrylate 
• 589-21-9 (4-bromophenyl)hydrazine 
• 1048364-45-9 tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate 
• 589-87-7 1,4-bromoiodobenzene 
• 27465-66-3 4-bromocinnamoyl chloride 
• 27784-76-5 tert-butyl diethylphosphonoacetate 

Downstream Products

• 1200-07-3 trans-4-bromocinnamic acid 
• 1000305-04-3 1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine 
• 1366440-28-9 C₁₅H₁₈BrNO 
• 1366440-18-7 tert-butyl 2-(4-bromophenyl)cyclopropanecarboxylate 
• 77255-26-6 trans-2-(4-bromophenyl)cyclopropanecarboxylic acid 
• 422518-34-1 C₂₈H₃₂BrNO₂ 

Relevant articles and documents

Selective Construction of C?C and C=C Bonds by Manganese Catalyzed Coupling of Alcohols with Phosphorus Ylides

Herein, we report the manganese catalyzed coupling of alcohols with phosphorus ylides. The selectivity in the coupling of primary alcohols with phosphorus ylides to form carbon-carbon single (C?C) and carbon-carbon double (C=C) bonds can be controlled by the ligands. In the conversion of more challenging secondary alcohols with phosphorus ylides the selectivity towards the formation of C?C vs. C=C bonds can be controlled by the reaction conditions, namely the amount of base. The scope and limitations of the coupling reactions were thoroughly evaluated by the conversion of 21 alcohols and 15 ylides. Notably, compared to existing methods, which are based on precious metal complexes as catalysts, the present catalytic system is based on earth abundant manganese catalysts. The reaction can also be performed in a sequential one-pot reaction generating the phosphorus ylide in situ followed manganese catalyzed C?C and C=C bond formation. Mechanistic studies suggest that the C?C bond was generated via a borrowing hydrogen pathway and the C=C bond formation followed an acceptorless dehydrogenative coupling pathway. (Figure presented.).

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

A chiral ligand mediated aza-conjugate addition strategy for the enantioselective synthesis of β-amino esters that contain hydrogenolytically sensitive functionality

Aza-conjugate addition of the lithium anion of N-trimethylsilyl-p-methoxybenzylamine to tert-butyl enoate acceptors, in the presence of a stoichiometric amount of enantiopure 1,2-dimethoxy-1,2-diphenylethane and excess trimethylsilyl chloride, affords ter