367-67-9

Basic information

• Product Name: 2-Bromo-5-nitrobenzotrifluoride
• Synonyms: 2-BROMO-5-NITROBENZOTRIFLUORIDE;2-BROMO-5-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE;5-NITRO-2-BROMOBENZOTRIFLUORIDE;LABOTEST-BB LT01143236;3-Trifluoromethyl-4-bromonitrobenzene;2-Bromo-5-nitrobenzotrifluorid;1-bromo-4-nitro-2-(trifluoromethyl)benzene;2-Bromo-5-nitrobenzotrifluoride98%
• CAS NO: 367-67-9
• Molecular Formula: C₇H₃BrF₃NO₂
• Molecular Weight: 270
• EINECS: 1312995-182-4
• Product Categories: Trifluoromethylbenzene serise;Benzene series;API intermediates;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 367-67-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 41-44 °C(lit.)
• Boiling Point: 87-88 °C3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: yellow crystals
• Density: 1.7750 (estimate)
• Vapor Pressure: 0.141mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• BRN: 2460260
• CAS DataBase Reference: 2-Bromo-5-nitrobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-nitrobenzotrifluoride(367-67-9)
• EPA Substance Registry System: 2-Bromo-5-nitrobenzotrifluoride(367-67-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 37/39-26-24/25
• RIDADR: 2306
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 367-67-9(Hazardous Substances Data)

Usage

Description

2-Bromo-5-nitrobenzotrifluoride is an organic compound characterized by its yellow crystalline structure. It is a derivative of benzotrifluoride with a bromine atom at the 2nd position and a nitro group at the 5th position, which contributes to its unique chemical properties and potential applications in various fields.

Uses

Used in Chemical Synthesis:
2-Bromo-5-nitrobenzotrifluoride is used as a key intermediate in the synthesis of various organic compounds due to its reactive bromine and nitro groups. Its ability to participate in a range of chemical reactions makes it a valuable building block for creating complex molecules with specific properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Bromo-5-nitrobenzotrifluoride is used as a starting material for the development of new drugs. Its unique structure can be modified to create novel compounds with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Material Science:
2-Bromo-5-nitrobenzotrifluoride is also utilized in the field of material science for the preparation of new polymers and materials with specific properties. Its trifluoromethyl group can enhance the stability and performance of the resulting materials, making it a useful component in the development of advanced materials for various applications.
Used in the Preparation of Specific Compounds:
2-Bromo-5-nitrobenzotrifluoride is used as a precursor in the preparation of new unsymmetrical diamine monomers, such as 6,4′-diamino-2′-trifluoromethyl-2-phenylbenzimidazole, which can be used in the development of advanced materials with unique properties. Additionally, it is used in the synthesis of 2,5-bis[(4-nitro-2-trifluoromethylphenoxy)-phenyl]diphenylphosphine oxide (BNTFDPO), a compound with potential applications in various fields.

InChI:InChI=1/C7H3BrF3NO2/c8-5-1-4(7(9,10)11)2-6(3-5)12(13)14/h1-3H

Upstream product

• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 
• 121-01-7 4-nitro-2-trifluoromethyl-aniline 
• 392-83-6 o-trifluoromethylphenyl bromide 

Downstream Products

• 347190-80-1 2,5-bis(4-nitro-2-trifluorophenyl)furan 
• 913173-50-9 N,N,N'-trimethyl-N'-(4-nitro-2-trifluoromethyl-phenyl)-ethane-1,2-diamine 
• 1137486-83-9 1,3,7-trimethyl-8-(4-nitro-2-(trifluoromethyl)phenyl)-xanthine 
• 364-11-4 1-bromo-4-iodo-2-(trifluoromethyl)benzene 
• 915779-75-8 4-dodecyloxy-2-trifluoromethylbenzonitrile 
• 89976-12-5 1-methyl-4-nitro-2-(trifluoromethyl) benzene 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 493038-92-9 1,2-dibromo-3-trifluoromethylbenzene 
• 384-16-7 2-bromo-1-chloro-3-(trifluoromethyl)benzene 
• 914225-53-9 2-bromo-3-trifluoromethyl-5-nitro-chlorobenzene 
• 865352-01-8 2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride 
• 98187-15-6 3-trifluoromethyl-4-nitrobenzoyl chloride 
• 320-37-6 4-nitro-2-(trifluoromethyl)benzoic acid 
• 125663-07-2 2,2-Bis[4-(4-nitro-2-trifluoromethylphenoxy)phenyl]-hexafluoropropane 

Relevant articles and documents

Fluorine-containing aromatic diamine compound and preparation method thereof, and fluorine-containing polyimide compound and preparation method thereof

The invention provides a fluorine-containing aromatic diamine compound and a preparation method thereof, and a fluorine-containing polyimide compound and a preparation method thereof. The fluorine-containing aromatic diamine compound has a structural general formula shown in the specification. The preparation method of the fluorine-containing aromatic diamine compound comprises the following stepsof: mixing materials including a compound A and a compound B, carrying out a first reaction to obtain a compound C, and carrying out a hydrogenation reaction on the compound C to obtain the fluorine-containing aromatic diamine compound. Raw materials of the fluorine-containing polyimide compound comprise the fluorine-containing aromatic diamine compound. The preparation method of the fluorine-containing polyimide compound comprises the following steps of: mixing materials including the fluorine-containing aromatic diamine compound and a dianhydride compound to obtain a mixture, and then carrying out a sixth reaction to obtain a precursor; and carrying out dehydration cyclization reaction on the pre-polymer, and carrying out post-treatment to obtain the fluorine-containing polyimide compound. The polyimide compound prepared from the fluorine-containing aromatic diamine compound provided by the invention is good in solubility, relatively high in transmittance and good in mechanical property.

Synthesis method of 2-bromo-5-fluorobenzotrifluoride

The invention relates to a synthesis method of 2-bromo-5-fluorobenzotrifluoride, belonging to the field of chemical synthesis. The method uses orthotrifluoromethyl aniline as the initial raw material, and comprises the following steps: (1) Sandmeyer bromination reaction; (2) nitration reaction; (3) catalytic hydrogenation reduction reaction; and (4) diazotization fluorination reaction. According to the method, the orthotrifluoromethyl aniline used as the raw material is subjected to Sandmeyer reaction bromination, nitration, hydrogenation reduction and diazotization fluorination to finally synthesize the 2-bromo-5-fluorobenzotrifluoride. The 2-bromo-5-fluorobenzotrifluoride product has the advantages of high purity (up to 99.0% or above), fewer impurity varieties and stable quality and properties.