37167-62-7

Basic information

• Product Name: METHYL ALPHA-BROMOPHENYLACETATE
• Synonyms: ALPHA-BROMOPHENYLACETIC ACID METHYL ESTER;METHYL A-BROMOPHENYLACETATE;METHYL (+/-)-ALPHA-BROMOPHENYLACETATE;METHYL ALPHA-BROMOPHENYLACETATE;Alpha-Bromophenyl Acid Methyl Ester;Methy α-bromophenylacetate ,97%
• CAS NO: 37167-62-7
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• Mol File: 37167-62-7.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 113 °C3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.46 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.554
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL ALPHA-BROMOPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL ALPHA-BROMOPHENYLACETATE(37167-62-7)
• EPA Substance Registry System: METHYL ALPHA-BROMOPHENYLACETATE(37167-62-7)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/39
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 37167-62-7(Hazardous Substances Data)

Usage

General Description

Methyl alpha-bromophenylacetate is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a derivative of phenylacetic acid with a methyl group and a bromine atom attached to the alpha carbon. METHYL ALPHA-BROMOPHENYLACETATE is often used as a building block for the synthesis of various pharmaceutical drugs and other organic compounds due to its ability to undergo various chemical reactions, including substitution and esterification. Methyl alpha-bromophenylacetate is considered to be a valuable intermediate in the production of chemicals with potential medicinal and biological properties, making it an important compound in the field of organic chemistry.

Upstream product

• 22979-35-7 Methyl phenyldiazoacetate 
• 2835-06-5 phenylglycin 
• 23535-28-6 methyl 2-phenyl-2-(piperidin-1-yl)acetate 
• 506-68-3 bromocyane 
• 29810-10-4 methyl α-(N,N-dimethylamino)phenylacetate 
• 67-56-1 methanol 
• 4870-65-9 2-bromophenylacetic acid 
• 64-17-5 ethanol 
• 2700-22-3 Benzylidenemalononitrile 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 611-71-2 MANDELIC ACID 
• 100-52-7 benzaldehyde 
• 4358-87-6 (RS)-methyl mandelate 

Downstream Products

• 131786-81-7 2-(3-pyridyl)-4-hydroxy-5-phenylthiazole 
• 126331-43-9 methyl 2-((2,2-dimethoxyethyl)amino)-2-phenylacetate? 
• 17841-30-4 methyl (±)-2-fluoro-2-phenylacetate 
• 25169-81-7 meso-2,3-diphenylsuccinic acid dimethyl ester 
• 19020-59-8 dl-2,3-diphenylsuccinic acid dimethyl ester 
• 32121-36-1 methyl 2-(naphthalen-2-yloxy)-2-phenylacetate 
• 32191-58-5 (2,4-Dichloro-phenoxy)-phenyl-acetic acid methyl ester 
• 174609-79-1 (+/-)-methyl 2-(1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)piperazin-4-yl)phenylacetate 
• 222293-56-3 (+/-)[(3,3-dihydro-3-amino-4-oxo-2-quinazolinyl)thio]-benzeneacetic acid methyl ester 
• 181039-82-7 [R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate 
• 181039-95-2 Methyl (RS)-[5-(1,3-benzodioxol-5-ylmethoxy)-2-cyano-phenoxy]-phenylacetate 
• 324011-38-3 α-[(3-amino-3,4-dihydro-5,6-dimethyl-4-oxo-thieno[2,3-d]pyrimidin-2-yl)thio]-phenylacetic acid methyl ester 
• 346416-54-4 4-(Methoxycarbonyl-phenyl-methyl)-piperazine-1-carboxylic acid ethyl ester 
• 853017-78-4 [(1R,2S,4S,5S)-4-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-4-methoxy-3,6-dioxa-bicyclo[3.1.0]hex-2-ylmethylsulfanyl]-phenyl-acetic acid methyl ester 

Relevant articles and documents

MALIC ENZYME INHIBITORS

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

Manganese/bipyridine-catalyzed non-directed C(sp3)–H bromination using NBS and TMSN3

A Mn(II)/bipyridine-catalyzed bromination reaction of unactivated aliphatic C(sp3)?H bonds has been developed using N-bromosuccinimide (NBS) as the brominating reagent. The reaction proceeded in moderate-to-good yield, even on a gram scale. The introduced bromine atom can be converted into fluorine and allyl groups.

Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide

A method for the bromination of α-diazo phenylacetate derivatives using cobalt(II) bromide is described. This bromination reaction features a short reaction time, broad substrate scope, operational simplicity, acid-free conditions, and gram-scalability. (Figure presented.).