37865-96-6

Basic information

• Product Name: 2-(2-BROMOETHYL)-2-METHYL-1,3-DIOXOLANE
• Synonyms: 2-(2-BROMOETHYL)-2-METHYL-1,3-DIOXOLANE;Bromoethylmethyldioxolane;2-(2-BROMOETHYL)-2-METHYL-1,3-DIOXOLANE 95+%
• CAS NO: 37865-96-6
• Molecular Formula: C₆H₁₁BrO₂
• Molecular Weight: 195.05
• Product Categories: Dioxanes & Dioxolanes;Dioxolanes
• Mol File: 37865-96-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 74 °C / 14mmHg
• Flash Point: 80.3 °C
• Appearance: /
• Density: 1,42 g/cm3
• Refractive Index: 1.4700-1.4740
• Storage Temp.: Refrigerator
• CAS DataBase Reference: 2-(2-BROMOETHYL)-2-METHYL-1,3-DIOXOLANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-BROMOETHYL)-2-METHYL-1,3-DIOXOLANE(37865-96-6)
• EPA Substance Registry System: 2-(2-BROMOETHYL)-2-METHYL-1,3-DIOXOLANE(37865-96-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 37865-96-6(Hazardous Substances Data)

Usage

General Description

2-(2-Bromoethyl)-2-methyl-1,3-dioxolane is a chemical compound with the molecular formula C6H11BrO2. It is a colorless liquid with a boiling point of 135-137°C. 2-(2-BROMOETHYL)-2-METHYL-1,3-DIOXOLANE is commonly used as a reagent in organic synthesis and is often employed in the manufacturing of pharmaceuticals and agrochemicals. It is also used as a solvent in various industrial processes. Additionally, it can act as a reactive intermediate in the synthesis of other organic compounds. However, it is important to handle this chemical with care as it is classified as a hazardous substance and may pose health and environmental hazards if not properly managed.

Upstream product

• 5754-32-5 2-(2-methyl-1,3-dioxolan-2-yl)ethanol 
• 26924-35-6 2-methyl-2-vinyl-1,3-dioxolane 
• 107-21-1 ethylene glycol 
• 78-94-4 methyl vinyl ketone 
• 6413-10-1 fructone 
• 28509-46-8 bromomethyl acetone 
• 15658-19-2 3,3-Ethylenedioxy-1-p-toluenesulfonate 

Downstream Products

• 85624-08-4 2-(2-Dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butyronitrile 
• 30834-43-6 1-Formyl-1-(3-oxobutyl)cyclohexane 
• 102670-91-7 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethoxy]-benzamide 
• 133661-33-3 2-Hydroxymethyl-6,6-dimethyl-1-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-cyclohex-2-enol 
• 457890-62-9 (3R,7aS)-5-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile 
• 81842-41-3 6,6-(ethylenedioxy)-3-<3,3-(ethylenedioxy)butyl>-3-(phenylsulfonyl)cyclohexene 
• 106185-66-4 5,5-Dimethyl-4-(3-oxo-butyl)-cyclohexane-1,3-dione 
• 71385-28-9 2-methyl-2-phenyl-1,5-hexanedione 
• 110087-06-4 2-<(4R,5R)-4,5-dibenzyloxyhept-2-enyl>-2-methyl-1,3-dioxolane 
• 71864-02-3 <3-(1,3-Dioxolan-2-yl)butyl>triphenylphosphonium bromide 
• 92596-24-2 2-[3-Isocyano-3-(toluene-4-sulfonyl)-nonyl]-2-methyl-[1,3]dioxolane 
• 92596-23-1 2-[(Z)-3-Isocyano-3-(toluene-4-sulfonyl)-non-6-enyl]-2-methyl-[1,3]dioxolane 

Relevant articles and documents

Efficient preparation of 2-methyl-1,3-dioxolane-2-ethanol and 2-(2-bromoethyl)-2-methyl-1,3-dioxolane from 4-hydroxy-2-butanone

2-Methyl-1,3-dioxolane-2-ethanol was prepared in 90% isolated yield from 4-hydroxy-2-butanone and ethylene glycol using a weak acid catalyst and ethyl acetate as the reaction solvent. 2-(2-Bromoethyl)-2-methyl-1,3-dioxolane was prepared in 75% isolated yield by bromination of 2-Methyl-1,3-dioxolane-2-ethanol with dibromotriphenylphosphorane. The reagent was prepared in situ by titrating triphenylphosphine with bromine at an ice-ethanol bath temperature. The target compounds are useful methyl vinyl ketone equivalents.

Microwave-assisted synthesis of substituted tetrahydropyrans catalyzed by ZrCl4 and its application in the asymmetric synthesis of exo- and endo-brevicomin

(Chemical Equation Presented) The ZrCl4-catalyzed deprotection of 1,3-dioxane/dioxalane and the simultaneous formation of 6-methoxy-substituted tetrahydropyrans proceeded under microwave irradiation in good yield. This synthetic methodology was

AN IMPROVED SYNTHESIS OF 2-(β-BROMOETHYL)-2-METHYL-1,3-DIOXOLANE, A USEFUL METHYL VINYL KETONE EQUIVALENT

A general method for the formation of β-bromo-ketals, and its application to an improved synthesis of 2-(β-bromoethyl)-2-methyl-1,3-dioxolane, a useful methyl vinyl ketone equivalent, in 82percent yield, are described.