41526-99-2

Basic information

• Product Name: Benzonitrile, 4-(4,5-dihydro-2-oxazolyl)-
• CAS NO: 41526-99-2
• Molecular Formula: C10H8N2O
• Molecular Weight: 172.186
• Mol File: 41526-99-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(4,5-dihydro-2-oxazolyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(4,5-dihydro-2-oxazolyl)-(41526-99-2)
• EPA Substance Registry System: Benzonitrile, 4-(4,5-dihydro-2-oxazolyl)-(41526-99-2)

Safety Data

• Hazardous Substances Data: 41526-99-2(Hazardous Substances Data)

Upstream product

• 141-43-5 ethanolamine 
• 105-07-7 4-cyanobenzaldehyde 
• 938461-52-0 N₁-(2-chloroethyl)-4-cyanobenzamide 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 619-65-8 4-cyanobenzoic Acid 
• 201230-82-2 carbon monoxide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 870-24-6 2-chloroethanamine hydrochloride 
• 623-26-7 terephthalonitrile 

Downstream Products

• 882045-60-5 2-(4-formylphenyl)-4,5-dihydrooxazole 
• 51575-77-0 1,4-Phenylene-2,2'-bisoxazole 
• 7426-75-7 1,4-bis(4,5-dihydro-2-oxazolyl)benzene 

Relevant articles and documents

Facile one-pot synthesis of 2-oxazoline

We developed a facile one-pot synthesis of 2-oxazolines from carboxylic acid and 2-chloroethyl isocyanate, involving amide bond formation and a following intramolecular cyclization using 4-dimethylaminopyridine as the catalyst. A large variety of functional groups are well tolerated by the mild reaction conditions to afford diverse 2-oxazolines in good to excellent yields. This reaction will keep the chirality of the isocyanate at position 1, the R2 substituted carbon. Microwave-assisted synthesis can further enhance the reaction yield and reduce the reaction time to 5 min. This method facilities the synthesis of 2-oxazolines for diverse applications, such as 2-oxazoline derived polymers and materials.

A 2 - substituted oxazoline or 2 - substituted piperazine synthetic method (by machine translation)

The invention discloses a method for synthesizing 2 - substituted oxazoline or 2 - substituted oxazine new method, by nitrile and amino ethanol or 3 - amino - 1 - propanol as raw material, in the absence of solvent, can be used for the recycling of the sulfur to induce synthesis of 2 - substituted oxazoline and 2 - substituted piperazine. The method of the invention has low cost, simple reaction process, mild reaction conditions, the reaction time is short, the yield and the like, is suitable for the industrial generation. (by machine translation)

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.