4173-65-3

Basic information

• Product Name: 1-Propanone, 3-[(4-methoxyphenyl)amino]-1-phenyl-
• CAS NO: 4173-65-3
• Molecular Formula: C16H17NO2
• Molecular Weight: 255.316
• Mol File: 4173-65-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-[(4-methoxyphenyl)amino]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-[(4-methoxyphenyl)amino]-1-phenyl-(4173-65-3)
• EPA Substance Registry System: 1-Propanone, 3-[(4-methoxyphenyl)amino]-1-phenyl-(4173-65-3)

Safety Data

• Hazardous Substances Data: 4173-65-3(Hazardous Substances Data)

Usage

General Description

1-Propanone, 3-[(4-methoxyphenyl)amino]-1-phenyl- is an organic compound with the chemical formula C17H17NO2. It is a derivative of 1-propanone, more commonly known as acetone, with an amino group attached to the third carbon atom and a phenyl and methoxy group attached to the first carbon atom. 1-Propanone, 3-[(4-methoxyphenyl)amino]-1-phenyl- is also known as 4'-methoxyacetophenone and is often used in the synthesis of various pharmaceuticals and organic chemical products. It is commonly utilized as a building block in the production of dyes, perfumes, and other organic compounds due to its aromatic and functional group properties. Additionally, it is used in the production of pharmaceutical intermediates and as a raw material in the synthesis of other chemical compounds.

Upstream product

• 104-94-9 4-methoxy-aniline 
• 768-03-6 Phenyl vinyl ketone 
• 98-86-2 acetophenone 
• 3506-36-3 3-dimethylaminopropiophenone 
• 2298-49-9 N-methyl-3-oxo-N-(3-oxo-3-phenylpropyl)-3-phenylpropan-1-aminium chloride 
• 5409-66-5 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine 
• 50-00-0 formaldehyd 
• 4747-13-1 α-methoxystyrene 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 701-56-4 4-methoxy-N,N-dimethylanilne 
• 94-38-2 3-diethylamino-1-phenyl-propan-1-one 

Downstream Products

• 1120358-80-6 3,4,5,6-tetrahydro-4-(p-anisyl)-2,7-diphenyl-2H-1,2,4-triazepine 
• 1325232-98-1 3,4,5,6-tetrahydro-4-(p-methoxyphenyl)-2-benzenesulfonyl-7-phenyl-2H-1,2,4-triazepine 
• 2535-59-3 4,5-dihydro-1-(4-methoxyphenyl)-3-phenyl-1H-pyrazole 
• 21918-04-7 3-(N-(4-methoxyphenyl)-N-nitrosoamino)-1-phenylpropane-1-one 

Relevant articles and documents

Stereoselective Construction of γ-Lactams via Copper-Catalyzed Borylacylation

A versatile and highly stereoselective borylative cyclization to generate polyfunctionalized γ-lactams has been developed. The stereoselective synthesis of these key ring systems is crucial due to their ubiquity in natural products. We report the diastero- and enantioselective construction of di- and trisubstituted γ-lactam cores, with examples containing an enantioenriched quaternary carbon.

Mannich bases as synthetic intermediates: Convenient synthesis of functionalized 1,2,4-triazepines, 1,4-diazepines and 1,5-diazocines

Transamination between the ketonic Mannich bases 1a, b and primary arylamines gave a series of ketonic sec-Mannich bases 2a - h. A variety of tetrahydro-1,2,4-triazepines 3a - f have been synthesized by treating the arylhydrazones of 2 with formaldehyde. A similar reaction with the benzenesulfonylhydrazone of 2b afforded 4. The 3-styryl-2H-1,2,4-triazepine 5 was obtained from the phenylhydrazone of 2a and cinnamaldehyde. Treatment of arylhydrazones of the 4-methoxystyryl keto base 7 with formaldehyde and cinnamaldehyde afforded the 3,4,5,6-tetrahydro-2H-1,2,4-triazepines 8a, b. Mannich reaction with 4-(p-hydroxyphenyl)-tetrahydro-1,2,4-triazepine 3d afforded the Mannich bases 9, 10 and 11. The reaction of 1b with o-phenylenediamine leads to the 1,5-benzodiazepine 13. The new tetrahydro- 1,4-diazepine and tetrahydro-1,5-diazocine Mannich bases 15 and 17 were obtained from 1b and ethylenediamine or 1,3-diaminopropane, respectively. The bi(piperidine) derivative 19 was obtained from 1a and 1,3-diaminopropane.

Mannich bases as synthetic intermediates: Alkylation of amines and diamines with bis-ketonic Mannich bases

The bis-ketonic Mannich base, N,N-bis(β-benzoylethyl)methylamine hydrochloride (1) reacts with primary arylamines and diamines to give ketonic sec-arylamines 3a-e and 4. The piperidines 7a-c were obtained from 1 and primary alkylamines, whereas the 1,4-diazepine derivative 10 was obtained from 1 and ethylenediamine. Treatment of the bis-base l,4-di[β-(N-morpholino) propionyl]benzene bis(hydrochloride) (11) with primary arylamines gave the corresponding bis-(sec-arylamines) 12a - b, whereas its reaction with o-phenylenediamine afforded the bis[1,5-benzodiazepine] ring system 14. The synthesis of the diazacyclophane ring system 15 has been achieved by treating 11 with piperazine. Attempted synthesis of 4-aza-[7]-paracyclophane (16) from 11 and benzylamine led to 17. The reaction of 1 or 11 with phenylhydrazine gave the 2-pyrazolines 18 and 19. Treatment of 3 or 4 with phenylhydrazine and formaldehyde afforded the 2H-1,2,4-triazepines 20a-c and the bis[2H-1,2,4-triazepine] ring system 21.