421595-81-5

Basic information

• Product Name: Imidazo[1,2-a]pyridin-7-amine (9CI)
• Synonyms: Imidazo[1,2-a]pyridin-7-amine (9CI);Imidazo[1,2-a]pyridin-7-amine;H-imidazo[1,2-a]pyridin-7-amine;7-Aminoimidazo[1,2-a]pyridine
• CAS NO: 421595-81-5
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15058
• Product Categories: AMINETERTIARY;Building Blocks;Imidazo[x,x-y]pyridine;organic building block
• Mol File: 421595-81-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• Refractive Index: 1.696
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.98±0.50(Predicted)
• CAS DataBase Reference: Imidazo[1,2-a]pyridin-7-amine (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridin-7-amine (9CI)(421595-81-5)
• EPA Substance Registry System: Imidazo[1,2-a]pyridin-7-amine (9CI)(421595-81-5)

Safety Data

• Hazardous Substances Data: 421595-81-5(Hazardous Substances Data)

Usage

General Description

Imidazo[1,2-a]pyridin-7-amine (9CI) is a chemical compound identified by the Chemical Abstracts Services or CAS with the number 143731-24-3. The exact physical properties, such as melting point, boiling point, or solubility, of this chemical are not detailed in available sources. Its specific applications are not clearly defined either. However, it belongs to the family of imidazopyridines and aminopyridines, which are frequently used in medicinal chemistry for the development of drugs given their properties of bonding with biological targets. Like other chemicals in its group, it should be handled with standard laboratory care. Detailed investigations are needed to make more precise conclusions about its properties and uses.

InChI:InChI=1/C7H7N3/c8-6-1-3-10-4-2-9-7(10)5-6/h1-5H,8H2

Upstream product

• 4532-25-6 7-chloroimidazo-[1,2-a]pyridine 
• 84249-14-9 2-amino-4-bromopyridine 
• 808744-34-5 7-bromoimidazo[1,2-a]pyridine 
• 421595-78-0 imidazo[1,2-a]pyridine-7-carbohydrazide 
• 421595-79-1 imidazo[1,2-a]pyridine-7-carbonyl azide 
• 372147-49-4 imidazo[1,2-a]pyridine-7-carboxylic acid ethyl ester 
• 421596-48-7 ethyl N-(imidazo[1,2-a]pyridin-7-yl)carbamate 

Downstream Products

• 421595-87-1 N-(triphenyl-λ⁵-phosphanylidene)imidazo[1,2-a]pyridin-7-amine 
• 1229384-42-2 3-[3-(4-fluoro-phenoxy)-benzyl]-piperidine-1-carboxylic acid imidazo[1,2-a]pyridin-7-ylamide 
• 1093209-62-1 C₂₂H₂₂ClN₅O₂ 
• 1375110-73-8 N-imidazo[1,2-a]pyridin-7-yl-3-oxo-3-phenylpropanamide 
• 1375110-61-4 9-(3',4',5'-trimethoxyphenyl)imidazo[2,1-f][1,6]naphthyridin-10(7H)-one 
• 1362752-18-8 2-cyano-1-(imidazo[1,2-a]pyridin-7-yl)-3-(4-(phenylsulfonyl)benzyl)guanidine 
• 421595-95-1 8-ethyl-9-methylimidazo[2,1-f][1,6]naphthyridine 

Relevant articles and documents

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides

The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.

Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120°C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.