4385-35-7 Usage
Description
3-Isochromanone is an organic compound that has been isolated from the fungus Nigrospora sp. PSU-F12. It is known for its chemical properties, which include forming lamellae. An improved Knoevenagel condensation of 3-isochromanone with aromatic aldehydes has been achieved through microwave irradiation on solid supports in the presence of various catalysts. Additionally, the synthesis of 3-isochromanone via Beayer-Villiger rearrangement has been reported.
Uses
Used in Pharmaceutical Industry:
3-Isochromanone is used as a starting reagent for the synthesis of BDPBI (7-bromo-1,4-dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)2H-isoquinolin-3-one dihydrochloride), which is a compound of interest in the pharmaceutical industry due to its potential applications in drug development and therapeutics.
Used in Chemical Synthesis:
3-Isochromanone serves as a valuable intermediate in the synthesis of various organic compounds. Its improved Knoevenagel condensation with aromatic aldehydes, achieved through microwave irradiation on solid supports and the presence of catalysts, highlights its utility in chemical synthesis processes.
Used in Research and Development:
The synthesis of 3-isochromanone via Beayer-Villiger rearrangement has been reported, making it a subject of interest for researchers and scientists working on new methods and techniques in organic chemistry. 3-ISOCHROMANONE's unique properties and synthesis pathways contribute to the advancement of knowledge in the field.
Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 4193, 1980 DOI: 10.1021/ja00532a034Tetrahedron Letters, 36, p. 8123, 1995 DOI: 10.1016/0040-4039(95)01692-B
Check Digit Verification of cas no
The CAS Registry Mumber 4385-35-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,8 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4385-35:
(6*4)+(5*3)+(4*8)+(3*5)+(2*3)+(1*5)=97
97 % 10 = 7
So 4385-35-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H8O2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-4H,5-6H2
4385-35-7Relevant articles and documents
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Spangler,Hokim
, p. 107 (1973)
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Nickel-Catalyzed Desymmetrizing Cyclization of 1,6-Dienes to Construct Quaternary Stereocenters
Zhao, Tian-Yuan,Li, Ke,Yang, Liang-Liang,Zhu, Shou-Fei,Zhou, Qi-Lin
supporting information, p. 3814 - 3817 (2021/05/26)
A highly enantioselective and diastereoselective nickel-catalyzed desymmetrizing cyclization of 1,6-dienes was developed by using chiral spiro phosphoramidite ligands. The reaction provides a new atom- and step-economical approach to chiral spiro lactones and analogues bearing a quaternary stereocenter.
Regioselective biocatalytic self-sufficient Tishchenko-type reactionviaformal intramolecular hydride transfer
Buljubasic, Isa,Hall, Mélanie,Laggner, Olivia,Merusic, Kemal,Reiter, Tamara,Tassano, Erika,Vogel, Andreas
supporting information, p. 6340 - 6343 (2020/06/21)
A self-sufficient nicotinamide-dependent intramolecular bio-Tishchenko-type reaction was developed. The reaction is catalyzed by alcohol dehydrogenases and proceeds through formal intramolecular hydride transfer on dialdehydes to deliver lactones. Regioselectivity on [1,1′-biphenyl]-2,2′-dicarbaldehyde substrates could be controlledviathe electronic properties of the substituents. Preparative scale synthesis provided access to substituted dibenzo[c,e]oxepin-5(7H)-ones.