494799-71-2

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 3-cyclohexyl-1-methyl-2-phenyl-, ethyl ester
• CAS NO: 494799-71-2
• Molecular Formula: C23H26N2O2
• Molecular Weight: 362.472
• Mol File: 494799-71-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 3-cyclohexyl-1-methyl-2-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 3-cyclohexyl-1-methyl-2-phenyl-, ethyl ester(494799-71-2)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 3-cyclohexyl-1-methyl-2-phenyl-, ethyl ester(494799-71-2)

Safety Data

• Hazardous Substances Data: 494799-71-2(Hazardous Substances Data)

Usage

Molecular class

pyrrolopyridine derivatives

Type of compound

ethyl ester derivative of pyrrolopyridine carboxylic acid

Substituents

cyclohexyl, methyl, and phenyl groups attached to nitrogen and carbon atoms

Use in pharmaceutical industry

as a building block for the synthesis of drugs targeting neurological disorders and cancer

Potential therapeutic use

as an anticancer agent for the treatment of various types of cancer.

Upstream product

• 108-94-1 cyclohexanone 
• 271-63-6 7-Azaindole 
• 494799-69-8 3-cyclohexyl-1-methyl-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid ethyl ester 
• 494799-68-7 3-cyclohexyl-1-methyl-1H-pyrrolo[2,3-b]pyridine-6-carbonitrile 
• 494799-67-6 3-cyclohexyl-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide 
• 494799-66-5 3-cyclohexyl-1H-pyrrolo[2,3-b]pyridine 7-oxide 
• 494799-65-4 3-cyclohexyl-1H-pyrrolo[2,3-b]pyridine 
• 494799-64-3 3-cyclohexenyl-1H-pyrrolo[2,3-b]pyridine 
• 494799-70-1 2-bromo-3-cyclohexyl-1-methyl-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid ethyl ester 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds

Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topologically related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole-tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC50 ～ 50 nM).