506421-62-1

Basic information

• Product Name: 2-(4-TrifluoroMethyl-phenyl)-quinoline
• Synonyms: 2-(4-TrifluoroMethyl-phenyl)-quinoline
• CAS NO: 506421-62-1
• Molecular Formula: C₁₆H₁₀F₃N
• Molecular Weight: 273.2525096
• Mol File: 506421-62-1.mol
• Article Data: 55

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-TrifluoroMethyl-phenyl)-quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TrifluoroMethyl-phenyl)-quinoline(506421-62-1)
• EPA Substance Registry System: 2-(4-TrifluoroMethyl-phenyl)-quinoline(506421-62-1)

Safety Data

• Hazardous Substances Data: 506421-62-1(Hazardous Substances Data)

Usage

Description

2-(4-TrifluoroMethyl-phenyl)-quinoline is a quinoline derivative with the molecular formula C18H12F3N, featuring a 4-trifluoromethylphenyl group attached to the quinoline structure. This chemical compound has potential applications in pharmaceutical research and drug discovery due to the various biological activities associated with quinoline derivatives, such as anticancer, antimicrobial, and anti-inflammatory properties. The presence of the 4-trifluoromethylphenyl group may enhance the compound's pharmacological properties and improve its biological activity.

Uses

Used in Pharmaceutical Research and Drug Discovery:
2-(4-TrifluoroMethyl-phenyl)-quinoline is used as a potential candidate in pharmaceutical research and drug discovery for its various biological activities. 2-(4-TrifluoroMethyl-phenyl)-quinoline's quinoline structure and the addition of the 4-trifluoromethylphenyl group may contribute to its enhanced pharmacological properties and improved biological activity, making it a promising candidate for further exploration and development in the field of medicine.
Further research and studies are needed to explore the potential uses and effects of 2-(4-TrifluoroMethyl-phenyl)-quinoline in various applications, as its full potential and specific applications have not been fully determined yet.

Upstream product

• 91-22-5 quinoline 
• 1613316-51-0 2-(4-(trifluoromethyl)phenyl)quinoline N-oxide 
• 1613-37-2 Quinoline N-oxide 
• 271-58-9 anthranil 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 173531-45-8 1‐(2,2‐dichlorovinyl)‐4‐(trifluoromethyl)benzene 
• 455-18-5 4-CF₃C₆H₄CN 
• 103-63-9 1-phenyl-2-bromoethane 
• 58106-57-3 (E)-3-(2-aminobenzene)acrylonitrile 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 2637-37-8 Quinoline-2-thiol 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 368-94-5 4-trifluoromethyl-benzoyl fluoride 
• 825-83-2 4-trifluoromethylbenzenethiol 

Downstream Products

• 1198359-68-0 2-(4-trifluoromethylphenyl)quinoline hydrobromide 
• 1198359-51-1 (R)-2-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

Direct C-H Arylation and Alkylation of Electron-Deficient Heteroaromatic Compounds with Organozinc Reagents

A direct and convenient method for the C-H arylation and alkylation of electron-deficient N-heteroarenes with readily available organozinc reagents has been developed. This transformation could be readily performed in the absence of a transition-metal catalyst and external oxidants, affording a wide range of substituted heteroarenes with good functional group tolerance in good to excellent yields. The developed simple protocol is scalable to the gram level and suitable for late-stage modification of bioactive molecules and drugs.

Visible-Light-Mediated Oxidative Cyclization of 2-Aminobenzyl Alcohols and Secondary Alcohols Enabled by an Organic Photocatalyst

This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols to produce quinolines at room temperature. This photocatalytic method employed anthraquinone as an organic small-molecule catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

Ruthenium-catalyzed acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones to quinolines in the presence of carbonate salt

A ruthenium complex bearing a functional 2,2′-bibenzimidazole ligand [(p-cymene)Ru(BiBzImH2)Cl][Cl] was designed, synthesized and found to be a general and highly efficient catalyst for the synthesis of quinolines via acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones in the presence of carbonate salt. It was confirmed that NH units in the ligand are crucial for catalytic activity. The application of this catalytic system for the scale-gram synthesis of biologically active molecular was also undertaken. Notably, this research exhibits new potential of metal–ligand bifuctional catalysts for acceptorless dehydrogenative reactions.