52667-88-6

Basic information

• Product Name: 1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE
• Synonyms: 1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE;1,4,7,10-Tetratosyl-1,4,7,10-tetraazacyclododecane;1,4,7,10-tetratosyl-1,4,7,10-tetraaza-cyclododecane;1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZA -CYCLODODECANE, TECH.;1,4,7,10-tetrakis(p-toluensulfonyl)-1,4,7,10-tetraazacyclododecane;1,4,7,10-Tetraazacyclododecane, 1,4,7,10-tetrakis[(4-Methylphenyl)sulfonyl]-;1,4,7,10-Tetratosyl-1,4,7,10-tetraazacyclododecane, technical;1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane
• CAS NO: 52667-88-6
• Molecular Formula: C₃₆H₄₄N₄O₈S₄
• Molecular Weight: 789.02
• EINECS: 414-030-0
• Mol File: 52667-88-6.mol
• Article Data: 25

Chemical Properties

• Melting Point: 275-279 °C(lit.)
• Boiling Point: 902.8±75.0 °C(Predicted)
• Appearance: /
• Density: 1.334±0.06 g/cm3(Predicted)
• PKA: -7.17±0.20(Predicted)
• CAS DataBase Reference: 1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE(52667-88-6)
• EPA Substance Registry System: 1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE(52667-88-6)

Safety Data

• Hazard Codes: Xi,N
• Statements: 43-50/53
• Safety Statements: 24-37-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 2
• Hazardous Substances Data: 52667-88-6(Hazardous Substances Data)

Usage

Description

1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE, also known as 1,4,7,10-Tetratosyl-1,4,7,10-tetraazacyclododecane, is a macrocyclic compound with potential applications in various fields due to its unique chemical properties.

Uses

Used in Electrochemistry:
1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE is used as a modifier for the preparation of electrodes. This application is particularly relevant in studying the electrochemical behavior of nicotinamide, a vital component in biological systems and energy metabolism.
Used in Ion-Selective Electrode Preparation:
In the field of analytical chemistry, 1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE is utilized as a key component in the development of ion-selective electrodes. Specifically, it is employed in the fabrication of coated wire chromium(III) ion-selective electrodes, which are essential tools for detecting and measuring chromium(III) ions in various samples.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 56187-04-3 1,4,7-tritosyl-1,4,7-triazaheptane 
• 52601-81-7 4-Methyl-N,N-bis<2-(methylsulfonyloxy)ethyl>benzolsulfonamid 
• 112-24-3 triethylentetramine 
• 10045-25-7 1,4,7,10-tetraazacyclododecane tetrahydrochloride 
• 70-55-3 toluene-4-sulfonamide 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 18522-92-4 sodium p-toluenesulfonamide 
• 97783-00-1 N,N',N-tris(p-toluenesulfonyl)-3,6,9-triazaundecane-1,11-di-p-toluenesulfonate 
• 5469-66-9 propane-1,3-diol ditosylate 
• 134448-29-6 1,7-bis(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane 
• 55442-07-4 N,N',N'',N'''-tetrakis-(p-tolylsulphonyl)-triethylenetetramine 
• 106-93-4 ethylene dibromide 
• 99142-41-3 Toluene-4-sulfonic acid 2-((toluene-4-sulfonyl)-{2-[(toluene-4-sulfonyl)-(2-{(toluene-4-sulfonyl)-[2-(toluene-4-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethyl}-amino)-ethyl ester 

Downstream Products

• 10045-25-7 1,4,7,10-tetraazacyclododecane tetrahydrochloride 
• 112193-77-8 1,4,7,10-tetraazacyclododecanetetrasulfate 
• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 60239-18-1 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane 
• 134448-29-6 1,7-bis(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane 
• 171416-77-6 1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane 
• 1369793-87-2 C₆₃H₁₀₄N₈O₁₄ 
• 1369793-88-3 C₆₄H₁₀₆N₈O₁₄ 
• 1369793-91-8 C₆₅H₁₀₈N₈O₁₄ 
• 1369793-93-0 C₆₆H₁₁₀N₈O₁₄ 
• 175854-39-4 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane 

Relevant articles and documents

DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX

To provide a metal complex that has high cancer cell toxicity and has DNA target and cyclen.SOLUTION: The present disclosure provides a dinuclear metal complex represented by the following formula (IV).SELECTED DRAWING: None

High-efficiency environment-friendly low-cost synthetic method of cycleanine

The invention discloses a high-efficiency environment-friendly low-cost synthetic method of cycleanine. The synthetic method comprises the following steps: step a, mixing triethylene tetramine, water,potassium carbonate and acetone to obtain a mixture, separately adding paratoluensulfonyl chloride into the mixture in different batches, and synthesizing a compound 2; step b, adding the compound 2and 1,2-dibromoethane into a solvent, and synthesizing a compound 3 in the presence of alkaline metal carbonate; step c, adding water and sulfuric acid into the compound 3, adding ethanol into a reaction product, precipitating, discharging, centrifuging, collecting a solid product, adding water and active carbon into the solid product, stirring, decoloring, centrifuging, collecting filtrate, adding hydrochloric acid, perfor ming salting-out crystallization, precipitating, discharging, centrifuging, collecting the solid product, and obtaining a compound 4; and step d, taking the compound 4 andan alkaline substance as raw materials, synthesizing a cycleanine crude product, extracting and purifying by virtue of methylbenzene-water, and obtaining the cycleanine. The high-efficiency environment-friendly low-cost synthetic method has the advantages of low cost, high efficiency, environmental friendliness.

Synthesis and characterization of binuclear Zn(II)-cyclen complexes bridged by α,ω-bis(4-methylphenoxy) alkanes

A series of novel α,ω-bis(4-methylphenoxy) alkane functionalized cyclen ligands were synthesized by the nucleophilic substitution reaction of 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane and α,ω-bis(4-bromomethylphenoxy) alkanes. The corresponding dimeric Zn(II)-cyclen complexes were obtained by reaction of these ligands with Zn(ClO4)2·6H2O. Ligands and complexes were characterized by FT-IR, 1H NMR, and elemental analysis. Springer Science+Business Media B.V. 2012.