52780-16-2

Basic information

• Product Name: 4-BROMOMETHYL BENZOYL CHLORIDE
• Synonyms: 4-BROMOMETHYL BENZOYL CHLORIDE(WX616001)
• CAS NO: 52780-16-2
• Molecular Formula: C₈H₆BrClO
• Molecular Weight: 233.49
• Mol File: 52780-16-2.mol
• Article Data: 39

Chemical Properties

• Melting Point: 33-34 °C
• Boiling Point: 145-150 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.606±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-BROMOMETHYL BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOMETHYL BENZOYL CHLORIDE(52780-16-2)
• EPA Substance Registry System: 4-BROMOMETHYL BENZOYL CHLORIDE(52780-16-2)

Safety Data

• Hazardous Substances Data: 52780-16-2(Hazardous Substances Data)

Usage

General Description

4-Bromomethyl benzoyl chloride is a chemical compound with the formula C8H6BrClO. It is a derivative of benzoyl chloride in which one of the hydrogen atoms on the phenyl ring is replaced by a bromomethyl group. The compound is a colorless to pale yellow liquid at room temperature and is highly reactive due to the presence of both a bromine and a chloride group. It is primarily used as a reagent in organic synthesis, specifically in the production of pharmaceutical compounds and agricultural chemicals. It is also used as a building block in the synthesis of various other organic compounds. Due to its reactivity and potential hazards, proper handling and safety precautions are necessary when working with 4-bromomethyl benzoyl chloride.

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 7726-95-6 bromine 
• 99-94-5 p-Toluic acid 
• 34241-39-9 azobisisobutyronitrile 
• 79-37-8 oxalyl dichloride 
• 6232-88-8 4-bromomethylbenzoic Acid 

Downstream Products

• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 26496-94-6 Ethyl 4-(bromomethyl)benzoate 
• 116274-14-7 p-bromomethylbenzoyl hydrazide 
• 152033-39-1 rac-2-(t-Butyl)-3-<4-<(dipropylamino)methyl>benzoyl>-1,3-oxazolidin-5-on 
• 35129-59-0 4-Bromomethyl benzoic acid thiophenyl ester 
• 35092-35-4 4-Bromomethyl benzoic acid phenyl ester 
• 158977-38-9 [16-(4-Bromomethyl-benzoyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl]-(4-bromomethyl-phenyl)-methanone 
• 113100-79-1 4-bromomethylbenzoic acid benzyl ester 
• 58914-40-2 4-(bromomethyl)benzamide 
• 566885-71-0 N-ethyl-p-bromomethylbenzamide 
• 118507-20-3 N-phenethyl-p-bromomethylbenzamide 
• 503543-74-6 N-(4-fluorophenyl)-4-bromomethylbenzamide 
• 108052-76-2 4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester 
• 913078-80-5 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamide 

Relevant articles and documents

Controlling the Spatial Organization of Liquid Crystalline Nanoparticles by Composition of the Organic Grafting Layer

Understanding how the spatial ordering of liquid crystalline nanoparticles can be controlled by different factors is of great importance in the further development of their photonic applications. In this paper, we report a new key parameter to control the mesogenic behavior of gold nanoparticles modified by rodlike thiols. An efficient method to control the spatial arrangement of hybrid nanoparticles in a condensed state is developed by changing the composition of the mesogenic grafting layer on the surface of the nanoparticles. The composition can be tuned by different conditions of the ligand exchange reaction. The thermal and optical behavior of the mesogenic and promesogenic ligands were investigated by using differential scanning calorimetry (DSC) and hot-stage polarized optical microscopy. The chemical structure of the synthesized hybrid nanoparticles was characterized by 1HNMR spectroscopy, thermogravimetric analysis (TGA), XPS, and elemental analysis, whereas the superstructures were examined by small-angle X-ray diffraction (SAXSRD) analysis. Structural studies showed that the organic sublayer made of mesogenic ligands is denser with an increasing the average ligand number, thereby separating the nanoparticles in the liquid crystalline phases, which changes the parameters of these phases. Softening nanocrystalline gold: An efficient method to control the spatial arrangement of liquid crystalline gold nanoparticles was developed by changing the composition of the mesogenic grafting layer. Structural studies showed that the organic sublayer is more dense with increasing average ligand number, thereby separating the nanoparticles in the liquid crystalline phases, which changes the parameters of these phases (see figure).

Pd-catalyzed sp-sp3cross-coupling of benzyl bromides using lithium acetylides

Organolithium-based cross-coupling reactions have emerged as an indispensable method to construct C-C bonds. These transformations have proven particularly useful for the direct and fast coupling of various organolithium reagents (sp, sp2, and sp3) with aromatic (pseudo) halides (sp2). Here we present an efficient method for the cross-coupling of benzyl bromides (sp3) with lithium acetylides (sp). The reaction proceeds within 10 min at room temperature and can be performed in the presence of organolithium-sensitive functional groups such as esters, nitriles, amides and boronic esters. The potential application of the methodology is demonstrated in the preparation of key intermediates used in pharmaceuticals, chemical biology and natural products.

1, 3-di-substituted-4-amino pyrazolopyrimidine compound, preparation method thereof and application of compound

The invention relates to a 1, 3-di-substituted-4-amino pyrazolopyrimidine compound, a preparation method thereof and an application of the compound. The compound is provided with a structure as shownin a formula I. The invention further relates to a preparation method of the compound with the structure as shown in the formula I and a medicine composition. The invention further provides an application of the compound and pharmaceutically acceptable salt thereof to preparation of MCL (mantle cell lymphoma) resistance medicines.

ONE-BEAD-TWO-COMPOUND MACROCYCLIC LIBRARY AND METHODS OF PREPARATION AND USE

A one-bead-two-compound combinatorial synthesis technique provides libraries of macrocyclic peptidomimetic compounds and compositions with use as ligands for the Ephrin type-A receptor 2 (EphA2). The one-bead-two-compound technique and libraries of macrocyclic compounds are useful as research tools in drug discovery and/or to treat or prevent a range of diseases or disorders.