54441-74-6Relevant articles and documents
Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes
Yin, Qi,Wen, Xiaolu,Chen, Yiwei,Gong, Xiangnan,Hu, Lin
supporting information, p. 7529 - 7534 (2021/10/02)
An efficient catalytic asymmetric [4 + 1] reaction, which features the use of simple β-keto esters as one-carbon nucleophiles and 5-succinimidothio-pent-2-enoates as four-atom bielectrophiles, has been developed in the presence of a bifunctional chiral ph
Synthesis and antibacterial activities of cadiolides A, B and C and analogues
Boulangé, Agathe,Parraga, Javier,Galán, Abraham,Cabedo, Nuria,Leleu, Stéphane,Sanz, Maria Jesus,Cortes, Diego,Franck, Xavier
, p. 3618 - 3628 (2015/07/27)
The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.
Design and synthesis of epicocconone analogues with improved fluorescence properties
Peixoto, Philippe A.,Boulang, Agathe,Ball, Malcolm,Naudin, Bertrand,Alle, Thibault,Cosette, Pascal,Karuso, Peter,Franck, Xavier
, p. 15248 - 15256 (2014/12/11)
Epicocconone is a natural latent fluorophore that is widely used in biotechnology because of its large Stokes shift and lack of fluorescence in its unconjugated state. However, the low photostability and quantum yields of epicocconone have limited its wid
