849024-42-6

Basic information

• Product Name: (Z)-3-(4-hydroxybenzoyl)-5-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one
• Synonyms: (Z)-3-(4-hydroxybenzoyl)-5-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one
• CAS NO: 849024-42-6
• Molecular Weight: 400.387
• Mol File: 849024-42-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-3-(4-hydroxybenzoyl)-5-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(4-hydroxybenzoyl)-5-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one(849024-42-6)
• EPA Substance Registry System: (Z)-3-(4-hydroxybenzoyl)-5-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one(849024-42-6)

Safety Data

• Hazardous Substances Data: 849024-42-6(Hazardous Substances Data)

Upstream product

• 4136-21-4 p-methoxybenzoylmethanol 
• 87769-44-6 6-(4-methoxyphenyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 54441-74-6 tert-butyl 3-(4-methoxyphenyl)-3-oxopropanoate 
• 849024-40-4 3-(4-methoxybenzoyl)-4-(4-methoxyphenyl)furan-2(5H)-one 
• 849024-39-1 3-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-5H-furan-2-one 
• 849024-38-0 4-bromo-3-[hydroxy-(4-methoxy-phenyl)-methyl]-5H-furan-2-one 
• 849024-41-5 (5Z)-3-(4-methoxybenzoyl)-5-(4-methoxybenzylidene)-4-(4-methoxyphenyl)furan-2(5H)-one 

Relevant articles and documents

Synthesis and antibacterial activities of cadiolides A, B and C and analogues

The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.

Short and efficient synthesis of cadiolide B

The first synthesis of cadiolide B has been achieved in 6 steps and 42% overall yield from 4-bromo-2(5H)-furanone. The pathway involves sequential, regiocontrolled introduction of the three furanone substituents by means of aldol reactions and Suzuki cros