87769-44-6

Basic information

• Product Name: 4H-1,3-Dioxin-4-one, 6-(4-methoxyphenyl)-2,2-dimethyl-
• CAS NO: 87769-44-6
• Molecular Formula: C13H14O4
• Molecular Weight: 234.252
• Mol File: 87769-44-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4H-1,3-Dioxin-4-one, 6-(4-methoxyphenyl)-2,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,3-Dioxin-4-one, 6-(4-methoxyphenyl)-2,2-dimethyl-(87769-44-6)
• EPA Substance Registry System: 4H-1,3-Dioxin-4-one, 6-(4-methoxyphenyl)-2,2-dimethyl-(87769-44-6)

Safety Data

• Hazardous Substances Data: 87769-44-6(Hazardous Substances Data)

Upstream product

• 54441-74-6 tert-butyl 3-(4-methoxyphenyl)-3-oxopropanoate 
• 67-64-1 acetone 
• 13422-77-0 3-(4-methoxy-phenyl)-3-oxo-propionic acid 
• 55991-69-0 5-(4-methoxyphenyl)-2,3-dihydro-2,3-furandione 
• 108-22-5 Isopropenyl acetate 
• 344448-31-3 2-(4-Methoxy-benzoyl)-3-oxo-butyric acid tert-butyl ester 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 965-01-5 3-(4-methoxyphenyl)-3-oxo-N-phenylpropanamide 
• 268536-10-3 6-anisyl-1,3-dioxine-4-thione 
• 849024-42-6 (Z)-3-(4-hydroxybenzoyl)-5-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one 
• 1314144-85-8 3-(4-methoxybenzoyl)-4-methylfuran-2(5H)-one 
• 849024-40-4 3-(4-methoxybenzoyl)-4-(4-methoxyphenyl)furan-2(5H)-one 
• 849024-41-5 (5Z)-3-(4-methoxybenzoyl)-5-(4-methoxybenzylidene)-4-(4-methoxyphenyl)furan-2(5H)-one 
• 1293991-71-5 3-(4-methoxybenzoyl)-6,6,9a-trimethyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione 
• 71200-91-4 4-(4-methoxyphenyl)-1,3-dihydro-2H-1,5-benzodiazepin-2-one 

Relevant articles and documents

Synthesis and antibacterial activities of cadiolides A, B and C and analogues

The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.

Versatile synthesis of acylfuranones by reaction of acylketenes with α-hydroxy ketones: Application to the one-step multicomponent synthesis of cadiolide B and its analogues

Functionalized acylfuranones have been prepared in a one-step procedure by thermal fragmentation of the corresponding dioxinones in the presence of hydroxy ketones in basic conditions. Multicomponent reactions also occur on addition of an aldehyde as a third reaction partner resulting in an expeditious access to cadiolide B and its analogues. A new method for the synthesis of acylfuranones is described based on the fragmentation of dioxinones to acylketenes followed by trapping with hydroxy ketones. Addition of an aldehyde as a third reaction partner leads to a supplementary aldolization/crotonization sequence resulting in an expeditious synthesis of cadiolide B and its analogues. Copyright

Synthesis of 1,3-dioxin-4-one Derivatives

A facile and general synthesis of 2,2-dimethyl-1,3-dioxin-4-one derivatives (1) is reported.Treatment of β-keto acids with a mixture of isopropenyl acetate and conc. sulfuric acid gave 2,2-dimethyl-1,3-dioxin-4-ones (1).Similar treatment of tert-butyl esters of β-keto acids also gave 1.KEYWORDS - 2,2-dimethyl-1,3-dioxin-4-one derivative; diketene-acetone adduct; diketene; acylketene; β-keto acid; β-keto ester