54879-64-0

Basic information

• Product Name: Benzenesulfonamide, N-[(4-methoxyphenyl)methyl]-4-methyl-
• CAS NO: 54879-64-0
• Molecular Formula: C15H17NO3S
• Molecular Weight: 291.371
• Mol File: 54879-64-0.mol
• Article Data: 49

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[(4-methoxyphenyl)methyl]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[(4-methoxyphenyl)methyl]-4-methyl-(54879-64-0)
• EPA Substance Registry System: Benzenesulfonamide, N-[(4-methoxyphenyl)methyl]-4-methyl-(54879-64-0)

Safety Data

• Hazardous Substances Data: 54879-64-0(Hazardous Substances Data)

Upstream product

• 54879-35-5 N-(2,2-Dimethoxy-ethyl)-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide 
• 2393-23-9 4-methoxy-benzylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 70-55-3 toluene-4-sulfonamide 
• 548464-35-3 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether 
• 640-60-8 toluene-4-sulfonic acid phenyl ester 
• 599-89-3 4-chlorophenyl p-toluenesulfonate 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 
• 3899-96-5 4-methylphenyl tosylate 
• 14674-38-5 N-(4-methoxybenzylidene)-p-toluenesulfonamide 
• 557-20-0 diethylzinc 
• 14674-38-5 (E)-N-(4-methoxybenzylidene)-4-methylbenzenesulfonamide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 1254692-10-8 pinacol (4-methylbenzenesulfonylamino)methaneboronate 

Downstream Products

• 167547-59-3 2-(4-methoxybenzyl)-3-oxo-3-phenylpropionic acid ethyl ester 
• 726-18-1 4,4'-dianisylmethane 
• 16133-88-3 benzyl 4-methoxybenzyl sulfide 
• 30881-24-4 3<(p-methoxyphenyl)methyl>-2,4-pentanedione 
• 102607-00-1 S-(4-methoxybenzyl) ethanethioate 
• 1333226-04-2 (4-methoxyphenethyl)trimethylsilane 
• 92-52-4 biphenyl 
• 53039-52-4 1-methyl-2-(4-methoxybenzyl) benzene 
• 834-14-0 p-benzylanizole 
• 26110-92-9 1-(2,2-dimethylpropyl)-4-methoxybenzene 
• 16510-27-3 1-(cyclopropylmethyl)-4-methoxybenzene 
• 56079-40-4 N,N-ditosyl-4-methoxybenzylamine 
• 1414850-51-3 N-(4-methoxybenzyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide 
• 1527501-89-8 N-(1-acetyl-1H-indol-2-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Synthesis of Polysubstituted Fused Pyrroles by Gold-Catalyzed Cycloisomerization/1,2-Sulfonyl Migration of Yndiamides

Yndiamides (bis-N-substituted alkynes) are valuable precursors to azacycles. Here we report a cycloisomerization/1,2-sulfonyl migration of alkynyl-yndiamides to form tetrahydropyrrolopyrroles, unprecedented heterocyclic scaffolds that are relevant to medicinal chemistry. This functional group tolerant transformation can be achieved using Au(I) catalysis that proceeds at ambient temperature, and a thermally promoted process. The utility of the products is demonstrated by a range of reactions to functionalize the fused pyrrole core.

Method for synthesizing N-alkyl sulfonamide in water

The invention discloses a method for synthesizing N-alkyl sulfonamide in water, in particular to a method for synthesizing an N-alkyl sulfonamide derivative from a sulfonamide derivative and alcohol,and a water-soluble iridium complex is adopted to catalyze the reaction of N-alkyl sulfonamide. Compared with the previous synthesis method, the method has the advantages that a reaction equivalent substrate is used in the reaction process, so that raw material waste is avoided; weak base is used, and reaction conditions are mild; non-toxic and harmless pure water is used as a solvent in the reaction, only water is generated as a by-product, the atom reaction economy is high, and the requirement of green chemistry is met.

Methyl-triflate-mediated dearylmethylation of: N -(arylmethyl)carboxamides via the retro-Mannich reaction induced by electrophilic dearomatization/rearomatization in an aqueous medium at room temperature

We have developed a protocol for the dearylmethylation of N-(arylmethyl)carboxamides under metal-free conditions in an aqueous medium at room temperature. This protocol involves methyl triflate-mediated successive C-C and C-N bond cleavages (retro-Mannich reaction) induced by electrophilic dearomatization/rearomatization. The dearomatization/rearomatization strategy can be expected to inspire the development of novel transformations based on the C-C bond cleavage in an environmentally benign manner.