5706-14-9

Basic information

• Product Name: 2-((4-METHOXYPHENYL)METHYLENE)INDAN-1-ONE
• Synonyms: 2-((4-METHOXYPHENYL)METHYLENE)INDAN-1-ONE;2-[(4-methoxyphenyl)methylidene]-2,3-dihydro-1H-inden-1-one
• CAS NO: 5706-14-9
• Molecular Formula: C₁₇H₁₄O₂
• Molecular Weight: 250.29
• Mol File: 5706-14-9.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 771.5°C at 760 mmHg
• Flash Point: 420.4°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 1E-23mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: 2-((4-METHOXYPHENYL)METHYLENE)INDAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-METHOXYPHENYL)METHYLENE)INDAN-1-ONE(5706-14-9)
• EPA Substance Registry System: 2-((4-METHOXYPHENYL)METHYLENE)INDAN-1-ONE(5706-14-9)

Safety Data

• Hazardous Substances Data: 5706-14-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C39H36ClNO5/c1-25-36(39(43)45-20-19-26-9-5-3-6-10-26)37(29-15-18-34(35(23-29)44-2)46-24-27-11-7-4-8-12-27)38-32(41-25)21-30(22-33(38)42)28-13-16-31(40)17-14-28/h3-18,23,30,37,41H,19-22,24H2,1-2H3

Upstream product

• 201230-82-2 carbon monoxide 
• 488151-80-0 3-(p-methoxyphenyl)-2-propen-1-yl methyl carbonate 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1202532-06-6 3-(4-methoxyphenyl)-1-(2-methylphenyl)prop-2-yn-1-one 
• 88-67-5 2-Iodobenzoic acid 
• 118-92-3 anthranilic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 61436-73-5 2-allylbenzoic acid 
• 83-33-0 inden-1-one 
• 105-13-5 4-Methoxybenzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 64666-42-8 1-methyl-1-indanol 
• 1383123-64-5 2-[3-(4-methoxyphenyl)prop-2-ynyl]benzaldehyde 

Downstream Products

• 84762-26-5 4-(p-methoxyphenyl)-3-cyano<5H>indeno<1,2-b>pyridine(1-phenyl)-2-one 
• 82607-03-2 4-(4-methoxyphenyl)<5H>indeno<1,2-b>pyridine-2(1H)-one 
• 82607-07-6 4-(4-Methoxy-phenyl)-2-oxo-2,3,4,5-tetrahydro-1H-indeno[1,2-b]pyridine-3-carboxylic acid amide 
• 76238-48-7 2-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-indan-1-ol 
• 87999-11-9 4-(4-Methoxy-phenyl)-3-phenyl-5H-indeno[1,2-b]pyridine 
• 118485-16-8 C₃₁H₂₆N₂O₂ 
• 118485-17-9 C₃₀H₂₃ClN₂O₂ 
• 84762-23-2 4-(p-methoxyphenyl)-3-cyano<5H>indeno<1,2-b>pyridine(1-methyl)-2-one 
• 84762-15-2 2-acetoxy-4-(p-methoxyphenyl)-3-cyano<5H>indeno<1,2-b>pyridine 
• 84762-14-1 4-(p-methoxyphenyl)-3-cyano<5H>indeno<1,2-b>pyridinium-2(1H)-one acetate 
• 135586-55-9 (E)-2-(4-acetoxybenzylidene)-2,3-dihydro-1H-inden-1-one 
• 135586-53-7 2--1-indanone 
• 16392-78-2 2-(4-methoxybenzyl)-indene 
• 13306-86-0 2-(4-methoxybenzyl)-2,3-dihydro-1H-inden-1-one 

Relevant articles and documents

Iron-catalyzed chemoselective hydride transfer reactions

A Diaminocyclopentadienone iron tricarbonyl complex has been applied in chemoselective hydrogen transfer reductions. This bifunctional iron complex demonstrated a broad applicability in mild conditions in various reactions, such as reduction of aldehydes over ketones, reductive alkylation of various functionalized amines with functionalized aldehydes and reduction of α,β-unsaturated ketones into the corresponding saturated ketones. A broad range of functionalized substrates has been isolated in excellent yields with this practical procedure.

Light-enabled, AlCl3-catalyzed regioselective intramolecular nucleophilic addition of non-nucleophilic alkyls to alkynes

Light-enabled, AlCl3-catalyzed regioselective intramolecular nucleophilic cyclization of alkynes using non-nucleophilic alkyls as the nucleophile is reported. Upon photoexcitation, o-alkylphenyl alkynyl ketones can be transferred into (E)-photoenols. Thus, a nucleophilic methylene is formed from the non-nucleophilic alkyl. An AlCl3 catalyst can stabilize the (E)-photoenol intermediate and facilitate further intramolecular nucleophilic cyclization. DFT calculations indicated that the AlCl3-catalyzed cyclization is the regioselectivity determining step.

In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives

Tyrosinase is a key enzyme responsible for melanin biosynthesis and is effective in protecting skin damage caused by ultraviolet radiation. As part of ongoing efforts to discover potent tyrosinase inhibitors, we systematically designed and synthesized thi